Table 1 Association between SNAT1 and p-Akt expression and clinicopathologic factors in breast cancer
From: Activation of SNAT1/SLC38A1 in human breast cancer: correlation with p-Akt overexpression
Clinicopathological variables | N (%) | SNAT1 (%) | P | p-Akt (%) | P | |||
|---|---|---|---|---|---|---|---|---|
Positive | Negative | Positive | Negative | |||||
Age(y) | ||||||||
<50 y | 96(45.7) | 58(60.4) | 38(39.6) | 0.987 | 64(66.7) | 32(33.3) | 0.509 | |
≥50 y | 114(54.3) | 69(60.5) | 45(39.5) | 71(62.3) | 43(37.7) | |||
pT | ||||||||
pT1/2 | 174(82.9) | 93(53.4) | 81(46.6) | <0.001 | 104(59.8) | 70(40.2) | 0.003 | |
pT3/4 | 36(17.1) | 34(94.4) | 2(5.6) | 31(86.1) | 5(13.9) | |||
pN | ||||||||
No | 136(64.8) | 58(42.6) | 78(57.4) | <0.001 | 64(47.1) | 72(52.9) | <0.001 | |
Yes | 74(35.2) | 69(93.2) | 5(6.8) | 71(95.9) | 3(4.1) | |||
Disease stage | ||||||||
I/II | 168(80.0) | 85(50.6) | 83(49.4) | <0.001 | 96(57.1) | 72(42.9) | <0.001 | |
III/IV | 42(20.0) | 42(97.6) | 1(2.4) | 39(92.9) | 3(7.1) | |||
Her2 | ||||||||
+ | 53(25.2) | 32(60.4) | 21(39.6) | 0.986 | 37(69.8) | 16(30.2) | 0.332 | |
- | 157(74.8) | 95(60.5) | 62(39.5) | 98(62.4) | 59(37.6) | |||
Ki67 | ||||||||
+ | 166(79.0) | 109(65.7) | 57(34.3) | 0.003 | 112(67.5) | 54(32.5) | 0.061 | |
- | 44(21.0) | 18(40.9) | 26(59.1) | 23(52.3) | 21(47.7) | |||
ER | ||||||||
+ | 117(55.7) | 60(47.2) | 57(48.7) | 0.002 | 67(57.3) | 50(42.7) | 0.017 | |
- | 93(44.3) | 67(72.0) | 26(28.0) | 68(73.1) | 25(26.9) | |||
PR | ||||||||
+ | 105(50.0) | 60(57.1) | 45(42.9) | 0.323 | 70(66.7) | 35(33.3) | 0.471 | |
- | 105(50.0) | 67(63.8) | 38(36.2) | 65(61.9) | 40(38.1) | |||
Total | 210 | 127(60.5) | 83(39.5) | 135(64.3) | 75(35.7) | |||