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Table 2 The association between Hb changes and the overall survival of cancer patients

From: Post-diagnosis hemoglobin change associates with overall survival of multiple malignancies – results from a 14-year hospital-based cohort of lung, breast, colorectal, and liver cancers

Cancers

Hb changes

Dead

Alive

HR (95% CI)*

P value

Validation†

Log-rank P

All cancers

 

By |∆Hb|

  

|∆Hb| ≤ 2.6

1585

1831

1.00

   
  

|∆Hb| > 2.6

1957

1302

1.40 (1.31-1.50)

4.5 x 10-22

100

1.6 x 10-39

 

By ∆Hb

  

−2.6 ≤ ∆Hb ≤ 2.6

1585

1831

1.00

   
  

∆Hb < −2.6

1357

975

1.35 (1.25-1.46)

3.0 x 10-15

100

 
  

∆Hb > 2.6

600

327

1.53 (1.39-1.69)

5.7 x 10-18

100

9.4 x 10-40

Lung cancer

 

By |∆Hb|

  

|∆Hb| ≤ 2.6

756

281

1.00

   
  

|∆Hb| > 2.6

1039

291

1.32 (1.20-1.46)

2.7 x 10-8

100

8.9 x 10-4

 

By ∆Hb

  

−2.6 ≤ ∆Hb ≤ 2.6

756

281

1.00

   
  

∆Hb < −2.6

774

246

1.25 (1.12-1.38)

3.7 x 10-5

97

 
  

∆Hb > 2.6

265

45

1.59 (1.38-1.84)

1.8 x 10-10

100

2.3 x 10-5

Breast cancer

 

By |∆Hb|

  

|∆Hb| ≤ 2.6

195

927

1.00

   
  

|∆Hb| > 2.6

170

447

1.49 (1.19-1.86)

4.3 x 10-4

100

6.5 x 10-10

 

By ∆Hb

  

−2.6 ≤ ∆Hb ≤ 2.6

195

927

1.00

   
  

∆Hb < −2.6

135

377

1.45 (1.14-1.84)

0.002

70

 
  

∆Hb > 2.6

35

70

1.65 (1.14-2.40)

0.008

58

1.5 x 10-9

Colorectal cancer

 

By |∆Hb|

  

|∆Hb| ≤ 2.6

360

506

1.00

   
  

|∆Hb| > 2.6

514

480

1.46 (1.27-1.68)

7.9 x 10-8

100

4.6 x 10-8

 

By ∆Hb

  

−2.6 ≤ ∆Hb ≤ 2.6

360

506

1.00

   
  

∆Hb < −2.6

281

299

1.46 (1.24-1.71)

3.4 x 10-6

100

 
  

∆Hb > 2.6

233

181

1.46 (1.23-1.73)

1.4 x 10-5

100

4.5 x 10-8

Liver cancer

 

By |∆Hb|

  

|∆Hb| ≤ 2.6

274

117

1.00

   
  

|∆Hb| > 2.6

234

84

1.45 (1.20-1.74)

7.9 x 10-5

100

0.016

 

By ∆Hb

  

−2.6 ≤ ∆Hb ≤ 2.6

274

117

1.00

   
  

∆Hb < −2.6

167

53

1.50 (1.23-1.83)

8.0 x 10-5

87

 
  

∆Hb > 2.6

67

31

1.33 (1.01-1.76)

0.044

34

0.011

  1. *Adjusted for age, gender, ethnicity, tumor stage, tumor grade, chemotherapy, radiation therapy, and surgery. †The number of times with P<0.01 in 100 resamplings of bootstrap internal validation. |∆Hb|, the maximum absolute Hb change during the first six months after cancer diagnosis. The cut off was determined using the median value (2.6 g/dL) of all cancer patients. ∆Hb<−2.6 indicated decreased Hb changes and ∆Hb>2.6 indicated increased Hb changes.
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BMC Cancer

ISSN: 1471-2407

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