| |
GFRα1 expression (n (%))
|
GFRα3 expression (n (%))
|
SDC3 expression (n (%))
|
|---|
|
Parameter
|
n
|
protein
|
P
|
protein
|
P
|
protein
|
P
|
|---|
|
Age (years)
|
|
≤ 35
|
16
|
9 (56.3)
|
0.249
|
9 (56.3)
|
0.078
|
5 (31.3)
|
0.768
|
|
35-55
|
92
|
34 (37.0)
| |
26 (28.3)
| |
24 (26.1)
| |
|
> 55
|
51
|
17 (33.3)
| |
15 (29.4)
| |
16 (31.4)
| |
|
Tumor size (cm)
|
|
≤ 2
|
13
|
6 (46.2)
|
0.135
|
4 (30.8)
|
0.37
|
5 (38.5)
|
0.555
|
|
2 ~ 5
|
115
|
38 (33.0)
| |
33 (28.7)
| |
30 (26.1)
| |
|
> 5
|
31
|
16 (51.6)
| |
13 (41.9)
| |
10 (32.3)
| |
|
Histologic type
|
|
Ductal
|
150
|
57 (38.0)
|
0.142
|
49 (32.7)
|
0.352
|
41 (27.3)
|
0.313
|
|
Lobular
|
6
|
2 (33.3)
| |
1 (16.7)
| |
2 (33.3)
| |
|
Mucinous
|
3
|
1 (33.3)
| |
0 (0)
| |
2 (66.7)
| |
|
Lymph node metastasis
|
|
0
|
55
|
9 (16.4)
|
0.001
|
9 (16.4)
|
0.006
|
15 (27.3)
|
0.977
|
|
1 ~ 3
|
55
|
24 (43.6)
| |
19 (34.5)
| |
16 (29.1)
| |
|
>3
|
49
|
27 (55.1)
| |
22 (44.9)
| |
14 (28.6)
| |
|
Grade
|
|
I
|
13
|
6 (46.2)
|
0.657
|
4 (30.8)
|
0.906
|
4 (30.8)
|
0.788
|
|
II
|
102
|
36 (35.2)
| |
31 (30.4)
| |
27 (26.5)
| |
|
III
|
44
|
18 (40.9)
| |
15 (34.1)
| |
14 (31.8)
| |
|
Stage
|
|
I-II
|
85
|
19 (22.4)
|
0.001
|
19 (22.4)
|
0.008
|
23 (27.1)
|
0.709
|
|
III-IV
|
74
|
41 (55.4)
| |
31 (41.9)
| |
22 (29.7)
| |
|
ER status^
|
|
-
|
94
|
39 (41.5)
|
0.24
|
27 (28.7)
|
0.374
|
24 (25.5)
|
0.351
|
|
+
|
65
|
21 (32.3)
| |
23 (35.4)
| |
21 (32.3)
| |
|
PR status^^
|
|
-
|
90
|
32 (35.6)
|
0.517
|
28 (31.1)
|
0.917
|
22 (24.4)
|
0.218
|
|
+
|
69
|
28 (40.6)
| |
22 (31.9)
| |
23 (33.3)
| |
|
HER-2 *
|
|
-
|
121
|
40 (33.1)
|
0.03
|
31 (25.6)
|
0.005
|
33 (27.3)
|
0.607
|
|
+
|
38
|
20 (52.6)
| |
19 (50.0)
| |
12 (31.6)
| |
- ^ ER positive required at least 10% staining nuclei.
- ^^ PR positive required at least 10% staining nuclei.
- HER-2 positive were 3+ or 2+ and FISH confirmed.
- Values in bold are significant (P < 0.05).
