Effects of hypoxia on human cancer cell line chemosensitivity

BMC Cancer

Table 2 Mean IC ₅₀ values for all tested drugs in normoxia A2780, ACHN, H69, MCF-7 and U-937

	A2780	ACHN	H69	MCF-7	U-937
5-FU	0.69 mM	>1.0 mM	>1.0 mM	N/A	0.14 mM
Acriflavine	6.2 μM	12 μM	27 μM	61 μM	4.6 μM
Bortezomib	11 nM	0.63 μM	15 nM	>3.0 μM	13 nM
Cisplatin	~9.3 μM	28 μM	0.11 mM	62 μM	2.8 μM
Digitoxin	0.11 μM	0.15 μM	>20 μM	N/A	70 nM
Digoxin	0.15 μM	0.81 μM	N/A	N/A	0.12 μM
Docetaxel	10 μM	4.0 μM	9.5 μM	25 μM	<16 nM
Doxorubicin	~1.8 μM	4.7 μM	23 μM	29 μM	0.15 μM
Etoposide	34 μM	11 μM	17 μM	>50 μM	0.17 μM
Gemcitabine	~4.8 mM	>5.0 mM	>5.0 mM	>5.0 mM	<1.6 μM
Irinotecan	38 μM	17 μM	~0.21 mM	93 μM	4.7 μM
Melphalan	18 μM	37 μM	0.13 mM	0.12 mM	6.0 μM
Mitomycin C	~53 μM	23 μM	37 μM	35 μM	0.70 μM
Rapamycin	~47 μM	28 μM	62 μM	N/A	5.1 μM
Sorafenib	7.2 μM	15 μM	~13 μM	43 μM	7.3 μM
Thalidomide	N/A	>0.1 mM	>0.1 mM	>0.1 mM	0.17 mM
Tirapazamine	0.15 mM	64 μM	0.15 mM	0.14 mM	24 μM
Topotecan	15 μM	10 μM	9.5 μM	<30 μM	0.12 μM
Vincristine	3.5 mM	<0.1 mM	N/A	N/A	<34 nM

ISSN: 1471-2407