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Table 2 Mean IC 50 values for all tested drugs in normoxia A2780, ACHN, H69, MCF-7 and U-937

From: Effects of hypoxia on human cancer cell line chemosensitivity

  A2780 ACHN H69 MCF-7 U-937
5-FU 0.69 mM >1.0 mM >1.0 mM N/A 0.14 mM
Acriflavine 6.2 μM 12 μM 27 μM 61 μM 4.6 μM
Bortezomib 11 nM 0.63 μM 15 nM >3.0 μM 13 nM
Cisplatin ~9.3 μM 28 μM 0.11 mM 62 μM 2.8 μM
Digitoxin 0.11 μM 0.15 μM >20 μM N/A 70 nM
Digoxin 0.15 μM 0.81 μM N/A N/A 0.12 μM
Docetaxel 10 μM 4.0 μM 9.5 μM 25 μM <16 nM
Doxorubicin ~1.8 μM 4.7 μM 23 μM 29 μM 0.15 μM
Etoposide 34 μM 11 μM 17 μM >50 μM 0.17 μM
Gemcitabine ~4.8 mM >5.0 mM >5.0 mM >5.0 mM <1.6 μM
Irinotecan 38 μM 17 μM ~0.21 mM 93 μM 4.7 μM
Melphalan 18 μM 37 μM 0.13 mM 0.12 mM 6.0 μM
Mitomycin C ~53 μM 23 μM 37 μM 35 μM 0.70 μM
Rapamycin ~47 μM 28 μM 62 μM N/A 5.1 μM
Sorafenib 7.2 μM 15 μM ~13 μM 43 μM 7.3 μM
Thalidomide N/A >0.1 mM >0.1 mM >0.1 mM 0.17 mM
Tirapazamine 0.15 mM 64 μM 0.15 mM 0.14 mM 24 μM
Topotecan 15 μM 10 μM 9.5 μM <30 μM 0.12 μM
Vincristine 3.5 mM <0.1 mM N/A N/A <34 nM
  1. N/A (not applicable) refers to an ambiguous IC50.