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Table 7 APOA1 rs670 A/A carriers has the worst post-surgery outcomes in lymph node-negative patients

From: The dyslipidemia-associated SNP on the APOA1/C3/A5 gene cluster predicts post-surgery poor outcome in Taiwanese breast cancer patients: a 10-year follow-up study

  Cox proportional hazard regression
Lymph node negative (n=121) Lymph node positive (n=90)
HR 95% CI P value HR 95% CI P value
Recurrence       
ER/PR negativitya 2.06 0.80-5.31 0.136 0.62 0.30-0.62 0.202
Age 1.01 0.96-1.05 0.788 1.01 0.98-1.01 0.582
BMI 0.95 0.84-1.08 0.450 1.02 0.92-1.02 0.703
Combined therapyb 2.02 0.83-4.93 0.120 2.12 0.85-5.29 0.107
APOA1 rs670 A/Ac 4.98 1.40-17.70 0.013 2.46 0.86-2.46 0.093
Mortality       
ER/PR negativitya 0.24 0.05-1.08 0.064 0.52 0.22-1.18 0.118
Age 1.05 0.98-1.13 0.196 1.02 0.99-1.06 0.262
BMI 0.89 0.71-1.11 0.296 1.03 0.91-1.16 0.648
Combined therapyb 1.83 0.41-8.18 0.430 2.65 0.89-7.88 0.081
APOA1 rs670 A/Ac 9.87 1.60-60.81 0.014 2.86 0.96-8.55 0.060
  1. NOTE: Bold type indicates p<0.050.
  2. a, compared with ER/PR positive.
  3. b, compared with TAM only.
  4. c, compared with APOA1 rs670 G/G.
  5. Abbreviations: BMI Body mass index, ER estrogen receptor, HR Hazard ratio, PR progesterone receptor.