The dyslipidemia-associated SNP on the APOA1/C3/A5 gene cluster predicts post-surgery poor outcome in Taiwanese breast cancer patients: a 10-year follow-up study

Table 7 APOA1 rs670 A/A carriers has the worst post-surgery outcomes in lymph node-negative patients

	Cox proportional hazard regression
	Lymph node negative (n=121)			Lymph node positive (n=90)
	HR	95% CI	P value	HR	95% CI	P value
Recurrence
ER/PR negativity^a	2.06	0.80-5.31	0.136	0.62	0.30-0.62	0.202
Age	1.01	0.96-1.05	0.788	1.01	0.98-1.01	0.582
BMI	0.95	0.84-1.08	0.450	1.02	0.92-1.02	0.703
Combined therapy^b	2.02	0.83-4.93	0.120	2.12	0.85-5.29	0.107
APOA1 rs670 A/A^c	4.98	1.40-17.70	0.013	2.46	0.86-2.46	0.093
Mortality
ER/PR negativity^a	0.24	0.05-1.08	0.064	0.52	0.22-1.18	0.118
Age	1.05	0.98-1.13	0.196	1.02	0.99-1.06	0.262
BMI	0.89	0.71-1.11	0.296	1.03	0.91-1.16	0.648
Combined therapy^b	1.83	0.41-8.18	0.430	2.65	0.89-7.88	0.081
APOA1 rs670 A/A^c	9.87	1.60-60.81	0.014	2.86	0.96-8.55	0.060

NOTE: Bold type indicates p<0.050.
^a, compared with ER/PR positive.
^b, compared with TAM only.
^c, compared with APOA1 rs670 G/G.
Abbreviations: BMI Body mass index, ER estrogen receptor, HR Hazard ratio, PR progesterone receptor.

ISSN: 1471-2407