From: Interrogating differences in expression of targeted gene sets to predict breast cancer outcome
 |  | Mortality | Recurrence | ||||
---|---|---|---|---|---|---|---|
Name | Mean (std dev) or N (%) | HR (95% CI) | P-value | Adj P-value | HR (95% CI) | P-value | Adj P-value |
Age | 59.8 (15.4) | 0.99 (0.97, 1) | 0.136 | 0.259 | 0.99 (0.97, 1) | 0.161 | 0.307 |
Tumor size (mm)Ï® | 29.6 (15.1) | 1.01 (1, 1.03) | 0.071 | 0.214 | 1.02 (1, 1.03) | 0.026 | 0.077 |
NodesÏ® | Â | Â | Â | Â | Â | Â | Â |
Pos | 134 (0.58) | 1 | - | - | 1 | - | - |
Neg | 97 (0.42) | 1.78 (1.1, 2.88) | 0.019 | 0.080 | 1.87 (1.17, 3.01) | 0.010 | 0.036 |
Hormone therapy | Â | Â | Â | Â | Â | Â | Â |
No | 162 (0.7) | 1 | - | - | 1 | - | - |
Yes | 71 (0.3) | 0.89 (0.52, 1.51) | 0.657 | 0.986 | 1.05 (0.63, 1.74) | 0.847 | 1.000 |
Chemotherapy | Â | Â | Â | Â | Â | Â | Â |
No | 152 (0.65) | 1 | - | - | 1 | - | - |
Yes | 81 (0.35) | 2.14 (1.33, 3.45) | 0.002 | 0.037 | 2.4 (1.5, 3.83) | <0.001 | 0.004 |
Radiation therapy | Â | Â | Â | Â | Â | Â | Â |
No | 191 (0.82) | 1 | - | - | 1 | - | - |
Yes | 42 (0.18) | 1.56 (0.89, 2.73) | 0.121 | 0.259 | 2.1 (1.25, 3.53) | 0.005 | 0.027 |
GradeÏ® | Â | Â | Â | Â | Â | Â | Â |
1 (well differentiated) | 13 (0.06) | 1 | - | - | 1 | - | - |
2 (intermediate) | 86 (0.42) | 2.37 (0.56, 9.94) | 0.239 | 0.419 | 1.54 (0.47, 5.05) | 0.479 | 0.839 |
3 or 4 (poorly differentiated or undifferentiated) | 105 (0.51) | 2.07 (0.49, 8.68) | 0.319 | 0.516 | 1.42 (0.43, 4.63) | 0.565 | 0.913 |
Disease stageÏ® | Â | Â | Â | Â | Â | Â | Â |
1 | 51 (0.22) | 1 | - | - | 1 | - | - |
2 | 143 (0.62) | 1.81 (0.85, 3.86) | 0.126 | 0.259 | 2.05 (0.97, 4.36) | 0.061 | 0.161 |
3 | 27 (0.12) | 3.41 (1.39, 8.35) | 0.007 | 0.039 | 3.69 (1.5, 9.03) | 0.004 | 0.027 |
4 | 8 (0.03) | 4.71 (1.54, 14.4) | 0.007 | 0.039 | 3.21 (0.85, 12.1) | 0.085 | 0.198 |
ER/PR | Â | Â | Â | Â | Â | Â | Â |
+/+ | 133 (0.57) | 1 | - | - | 1 | - | - |
+/- | 17 (0.07) | 1.98 (0.82, 4.79) | 0.128 | 0.259 | 3.68 (1.79, 7.58) | <0.001 | 0.004 |
-/+ | 30 (0.13) | 2.1 (1.05, 4.21) | 0.037 | 0.128 | 1.77 (0.86, 3.63) | 0.118 | 0.249 |
-/- | 53 (0.23) | 2.26 (1.3, 3.94) | 0.004 | 0.039 | 2.1 (1.19, 3.7) | 0.010 | 0.036 |