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Table 1 Main characteristics of studies included in the meta-analysis of the diagnostic accuracy of CTCs detection in gastric cancer

From: Diagnostic accuracy of circulating tumor cells detection in gastric cancer: systematic review and meta-analysis

First author Year of publication Country of origin Maker used CTC/patients CTC/controls tp fp fn tn Patient age(years) mean(range) Tumor histology Tumor stage Data about prognosis Inclusion criteria Detection method
Aihara 1997 Japan Keratin 19 0/49 0/50 0 0 49 50 NR NR I-IV No UICC RT-PCR
Bertazza 2009 Italy Survivin 69/70 0/20 69 0 1 20 68(28–90)† Yes I-IV Yes UICC qRT-PCR
CK19 68/70 0/20 68 0 2 20
CEA 30/70 0/20 30 0 40 20
VEGF 27/70 0/20 27 0 43 20
Cui 2011 China piR-651 66/93 6/32 66 6 27 26 preoperative:60 ± 17; postoperative:63 ± 14 Yes I-IV Np National Comprehensive Cancer Network clinical practice guideline of oncology qRT-PCR
piR-823 75/93 6/32 75 6 18 26
Hiraiwa 2008 Japan EpCAM 17/41 0/41 17 0 24 41 NR Yes I-IV Yes AJCC Immunological
Ikeguchi 2005 Japan CEA 0/59 0/15 0 0 59 15 66.3(26–86) Yes I-IV Yes Japanese Classification of Gastric Carcinoma RT-PCR
Ikeguchi 2003 Japan CEA 1/55 0/40 1 0 54 40 65.4 Yes I-IV No Japanese Classification of Gastric Carcinoma RT-PCR
CK19 0/55 0/40 0 0 55 40
CK20 15/55 2/40 15 2 40 38
Ito 2010 Japan GFP 27/27 0/80 27 0 0 80 56.1(39–76) Yes I-IV No AJCC Immunological
Koga 2008 Japan CK19 8/69 0/14 8 0 61 14 65.7 Yes I-IV No Japanese Classification of Gastric Carcinoma qRT-PCR
CK20 10/69 0/14 10 0 59 14
Majima 2000 Japan CK19 5/52 0/14 5 0 47 14 NR NR I-IV Yes Creteria of the UICC RT-PCR
CK20 5/52 1/14 5 1 47 13
Noh 1999 Korea CEA 16/35 0/9 16 0 19 9 54.5(26–71) Yes I/III/IV No AJCC RT-PCR
Qiao 2007 China CK20 9/40 0/20 9 0 31 20 62.2 Yes   No NR RT-PCR
Ren 2011 China EpCAM 20/33 0/60 20 0 13 60 NR Yes I-IV No AJCC Immunological
Uen 2006 China c-Met 32/52 2/36 32 2 20 34 60.0(34–84) Yes I-IV Yes AJCC RT-PCR
MUC1 37/52 3/36 37 3 15 33
Wang 2009 China MAGE-1 19/40 0/20 19 0 21 20 55.7(27–77) Yes I-IV No AJCC RT-PCR
MAGE-3 10/40 0/20 10 0 30 20
Wu 2006 China hTERT 52/64 14/80 52 14 12 66 60.5(36–84) Yes I-IV Yes AJCC RT-PCR
CK19 50/64 12/80 50 12 14 68
CEA 53/64 19/80 53 19 11 61
MUC1 54/64 13/80 54 13 10 67
Wu 2006 China hTERT 26/42 0/30 26 0 16 30 60.2(34–84) Yes I-IV Yes AJCC RT-PCR
CK19 29/42 1/30 29 1 13 29
CK20 26/42 1/30 26 1 16 29
CEA 33/42 0/30 33 0 9 30
Yang 2002 China CEA 24/40 1/34 24 1 16 33 51.2(38–76) Yes I-IV No AJCC RT-PCR
Yeh 1998 China CK19 7/34 0/33 7 0 27 33 57(31–81)† Yes I-IV Yes UICC RT-PCR
Zhang 2007 China CEA 4/45 0/13 4 0 41 13 60.5(42–78) Yes I-IV No UICC RT-PCR
Zhou 2010 China miR-106a 43/90 3/27 43 3 47 24 male: 62.3; female:59.2 Yes NR No UICC RT-PCR
MiR-17 47/90 2/27 47 2 43 25
  1. †: median (range) of patient age (years).