Table 3 Significantly enriched pathways with reduced methylation in immature teratomas compared with mature teratomas
From: DNA methylation analysis reveals distinct methylation signatures in pediatric germ cell tumors
Ingenuity Canonical Pathway | Genes | p-value |
|---|---|---|
Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency | SOX2,CASP6,SPP1,BMI1,RARA,PARP1 | 0.0015 |
Axonal Guidance Signaling | GLI2,BMP4,BDNF,BMP2,PIK3R1,EGF,VEGFB,KRAS,LIMK1,PTCH2,EPHB1,GLI3,NGFR,DCC,EFNB3,ERBB2,ITGB1,TUBB3,WNT2B,MMP10,EPHA3,PDGFB,NTRK2,EPHA5,EPHA2 | 0.0045 |
Human Embryonic Stem Cell Pluripotency | BMP4,BDNF,BMP2,PIK3R1,FGFR1,WNT2B,TDGF1,FGFR2,PDGFB,APC,SOX2,FGFR3,NTRK2,PDGFRA,CTNNB1,PDGFRB | 0.0084 |
PAK Signaling | ITGB1,MYLK,PIK3R1,PDGFRA,KRAS,EPHA3,TNF,PDGFB,PDGFRB,LIMK1 | 0.01 |
PDGF Signaling | ABL2,PIK3R1,MAP3K1,PDGFRA,CAV1,KRAS,EIF2AK2,PDGFB,PDGFRB | 0.01 |
NF-κB Signaling | MAP2K6,BMP4,BMP2,PIK3R1,FGFR1,EGF,FGFR2,KRAS,DDR1,FGFR3,NTRK2,NGFR,KDR,INS,PDGFRA,EIF2AK2,TNF,PDGFRB | 0.02 |
PTEN Signaling | ITGB1,PIK3R1,FGFR1,FGFR2,KRAS,CCND1,DDR1,FGFR3,NTRK2,NGFR,KDR,PDGFRA,PDGFRB | 0.03 |
Transcriptional Regulatory Network in Embryonic Stem Cells | SOX2,ISL1,PAX6 | 0.03 |
Estrogen Biosynthesis | CYP2E1,HSD17B12,CYP1B1 | 0.03 |
HER-2 Signaling in Breast Cancer | ITGB1,PIK3R1,EGF,KRAS,ERBB3,ERBB2,CCND1,AREG/AREGB | 0.04 |
Gap Junction Signaling | TUBB3,GUCY2D,PIK3R1,CAV1,EGF,KRAS,CTNNB1,HTR2A | 0.04 |
Actin Cytoskeleton Signaling | ITGB1,MYLK,PIK3R1,FGF9,INS,EGF,KRAS,PDGFB,APC,FGF1,LIMK1,MATK | 0.04 |
Embryonic Stem Cell Differentiation into Cardiac Lineages | SOX2,ISL1 | 0.04 |