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Table 3 Significantly enriched pathways with reduced methylation in immature teratomas compared with mature teratomas

From: DNA methylation analysis reveals distinct methylation signatures in pediatric germ cell tumors

Ingenuity Canonical Pathway Genes p-value
Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency SOX2,CASP6,SPP1,BMI1,RARA,PARP1 0.0015
Axonal Guidance Signaling GLI2,BMP4,BDNF,BMP2,PIK3R1,EGF,VEGFB,KRAS,LIMK1,PTCH2,EPHB1,GLI3,NGFR,DCC,EFNB3,ERBB2,ITGB1,TUBB3,WNT2B,MMP10,EPHA3,PDGFB,NTRK2,EPHA5,EPHA2 0.0045
Human Embryonic Stem Cell Pluripotency BMP4,BDNF,BMP2,PIK3R1,FGFR1,WNT2B,TDGF1,FGFR2,PDGFB,APC,SOX2,FGFR3,NTRK2,PDGFRA,CTNNB1,PDGFRB 0.0084
PAK Signaling ITGB1,MYLK,PIK3R1,PDGFRA,KRAS,EPHA3,TNF,PDGFB,PDGFRB,LIMK1 0.01
PDGF Signaling ABL2,PIK3R1,MAP3K1,PDGFRA,CAV1,KRAS,EIF2AK2,PDGFB,PDGFRB 0.01
NF-κB Signaling MAP2K6,BMP4,BMP2,PIK3R1,FGFR1,EGF,FGFR2,KRAS,DDR1,FGFR3,NTRK2,NGFR,KDR,INS,PDGFRA,EIF2AK2,TNF,PDGFRB 0.02
PTEN Signaling ITGB1,PIK3R1,FGFR1,FGFR2,KRAS,CCND1,DDR1,FGFR3,NTRK2,NGFR,KDR,PDGFRA,PDGFRB 0.03
Transcriptional Regulatory Network in Embryonic Stem Cells SOX2,ISL1,PAX6 0.03
Estrogen Biosynthesis CYP2E1,HSD17B12,CYP1B1 0.03
HER-2 Signaling in Breast Cancer ITGB1,PIK3R1,EGF,KRAS,ERBB3,ERBB2,CCND1,AREG/AREGB 0.04
Gap Junction Signaling TUBB3,GUCY2D,PIK3R1,CAV1,EGF,KRAS,CTNNB1,HTR2A 0.04
Actin Cytoskeleton Signaling ITGB1,MYLK,PIK3R1,FGF9,INS,EGF,KRAS,PDGFB,APC,FGF1,LIMK1,MATK 0.04
Embryonic Stem Cell Differentiation into Cardiac Lineages SOX2,ISL1 0.04