Figure 3
From: A link between premenopausal iron deficiency and breast cancer malignancy
Host iron deficiency stimulates Notch but not TGF- β , and Wnt signaling. (A) Iron deficiency increased mRNA expression of Notch 2, 3, 4, their receptors Jagged 1, 2 and Hes1 by qPCR. (B) No significant changes for TGF-β signaling pathway components, TGF-β1, Smad 2, and Smad3. (C) No significant changes for Wnt signaling pathway components, LRP5, LRP6, and Wnt3a. *: Significantly different from the group of mice fed 350 ppm Fe diet.