Vitamin D analogs enhance the anticancer activity of 5-fluorouracil in an in vivomouse colon cancer model

BMC Cancer

Table 6 Tumor growth delay values for each group and survival analysis of mice

Group	The time needed for tumors to reach			ILS [%]	N
	the volume of 1 cm³
	TGD [day]	ΔTGD_control	ΔTGD_cytostatic
	TGD [day]	[day]	[day]
Control	24	---		---	8
5-FU	47	23		76^**	6
5-FU + PRI-2205	50	27	3	97	6
5-FU + PRI-2191	56	32	9	105^**	6

N Number of mice in group, TGD Tumor growth delay, ΔTGD_control = TGD _{treated group}–TGD_control, ΔTGD_cytostatic = TGD_{treated group}–TGD_cytostatic, ILS increase in life span, ^** P < 0.01 as compared to control.
Mice bearing s.c. MC38 colon cancer cells were i.v. injected with 5-FU at a dose of 100 mg/kg/day from days 20 to 34. When 5-FU reduced tumor volume by about 90% in comparison to the control group, the administration of analogs was initiated (after administration of the cytostatic drug ended). Both analogs were administrated s.c., three times a week from days 35 to 56, analog PRI-2191 at a dose of 1 μg/kg/day and PRI-2205 at a dose of 10 μg/kg/day.

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