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Table 6 Tumor growth delay values for each group and survival analysis of mice

From: Vitamin D analogs enhance the anticancer activity of 5-fluorouracil in an in vivomouse colon cancer model

Group The time needed for tumors to reach ILS [%] N
the volume of 1 cm3
TGD [day] ΔTGDcontrol ΔTGDcytostatic
[day] [day]
Control 24 ---   --- 8
5-FU 47 23 76** 6
5-FU + PRI-2205 50 27 3 97 6
5-FU + PRI-2191 56 32 9 105** 6
  1. N Number of mice in group, TGD Tumor growth delay, ΔTGDcontrol = TGD treated group–TGDcontrol, ΔTGDcytostatic = TGDtreated group–TGDcytostatic, ILS increase in life span, ** P < 0.01 as compared to control.
  2. Mice bearing s.c. MC38 colon cancer cells were i.v. injected with 5-FU at a dose of 100 mg/kg/day from days 20 to 34. When 5-FU reduced tumor volume by about 90% in comparison to the control group, the administration of analogs was initiated (after administration of the cytostatic drug ended). Both analogs were administrated s.c., three times a week from days 35 to 56, analog PRI-2191 at a dose of 1 μg/kg/day and PRI-2205 at a dose of 10 μg/kg/day.