N Number of mice in group, TGD Tumor growth delay, ΔTGDcontrol = TGD treated group–TGDcontrol, ΔTGDcytostatic = TGDtreated group–TGDcytostatic, ILS increase in life span, **P < 0.01 as compared to control.
Mice bearing s.c. MC38 colon cancer cells were i.v. injected with 5-FU at a dose of 100 mg/kg/day from days 20 to 34. When 5-FU reduced tumor volume by about 90% in comparison to the control group, the administration of analogs was initiated (after administration of the cytostatic drug ended). Both analogs were administrated s.c., three times a week from days 35 to 56, analog PRI-2191 at a dose of 1 μg/kg/day and PRI-2205 at a dose of 10 μg/kg/day.