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Table 4 The effect of vitamin D analog (in the most effective dose, administered orally) alone or in combination with 5-FU on tumor growth and body weight of mice bearing subcutaneously MC38 colon cancer

From: Vitamin D analogs enhance the anticancer activity of 5-fluorouracil in an in vivomouse colon cancer model

Analog (AN) 5-FU AN TGI [%] on the 21st day of the experiment Maximal decrease
in body weight [%]
5-FU AN 5-FU + AN %H TGI Effect 5-FU AN 5-FU + AN
PRI-2191 100 mg/kg 1 μg/kg 72 12 81 75 Synergism 2 5 15
PRI-2205 100 mg/kg 10 μg/kg 72 6 73 73 No effect 2 5 5
  1. Vitamin D analog was administered orally (p.o.), three times a week.
  2. AN Analog of vitamin D, TGI Tumor growth inhibition; %H TGI, Hypothetical tumor growth inhibition; Number of mice in each group - 8.
  3. Mice bearing s.c. MC38 colon cancer cells were i.v. injected with 5-FU at a dose of 100 mg/kg/day from days 9 to 23 and/or vitamin D analogs: PRI-2191 at a dose of 1 μg/kg/day or PRI-2205 at a dose of 10 μg/kg/day. Both analogs were administrated p.o., three times a week from days 12 to 28.