Analog (AN) | 5-FU | AN | TGI [%] on the 21st day of the experiment | Maximal decrease | ||||||
---|---|---|---|---|---|---|---|---|---|---|
in body weight [%] | ||||||||||
5-FU | AN | 5-FU + AN | %H TGI | Effect | 5-FU | AN | 5-FU + AN | |||
PRI-2191 | 100 mg/kg | 1 μg/kg | 72 | 12 | 81 | 75 | Synergism | 2 | 5 | 15 |
PRI-2205 | 100 mg/kg | 10 μg/kg | 72 | 6 | 73 | 73 | No effect | 2 | 5 | 5 |