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Table 3 Wee1 expression in relation to cell cycle proteins

From: High expression of wee1 is associated with malignancy in vulvar squamous cell carcinoma patients

Variables1 Total Nucleus Cytoplasm
  N High (%) P 2 High (%) P 2
CDC25C cytoplasm     0.9    0.015
 Low (≤ 3) 110 29 (26)   48 (44)  
 High (> 3) 187 48 (26)   109 (58)  
Phospho-CDC25C (Ser216) cytoplasm     <0.001    0.18
 Low (≤ 3) 147 23 (16)   72 (49)  
 High (>3) 150 54 (36)   85 (57)  
Phospho-CDC25C (Ser216) nucleus     0.002    0.16
 Low (−) 86 33 (38)   40 (46)  
 High (+) 211 44 (21)   117 (55)  
14-3-3β cytoplasm     0.7    0.008
 Low (≤ 1) 61 17 (28)   23 (38)  
 High (>1) 236 60 (25)   134 (57)  
14-3-3ϵ cytoplasm     1.0    0.04
 Low (≤ 1) 42 11 (26)   16 (38)  
 High (>1) 255 66 (26)   141 (55)  
14-3-3η cytoplasm     0.07    0.003
 Low (≤ 3) 138 29 (21)   60 (43)  
 High (>3) 159 48 (30)   97 (61)  
p21 nucleus3     0.04    0.5
 Low (−) 119 21 (18)   62 (52)  
 High (+) 88 26 (30)   50 (57)  
Cyclin A nucleus3     0.004    0.2
 Low (< 5%) 61 6 (10)   29 (48)  
 High (≥ 5%) 146 41 (28)   83 (57)  
  1. 1Have been studied in previous reports [1619].
  2. 2Pearson chi-square.
  3. 3207 of the 297 vulvar carcinomas have been tested for this marker.
  4. High: Wee1 expression in nucleus ≥ 6 and in cytoplasm > 0.