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Table 1 Human breast cancer values for doubling time

From: Detection of cancer before distant metastasis

   Tumor Doubling time (months)
Publication N size (mm) Median Range
Lundgren 1977 [27] 13 N/A 6.9 1.4 – 13.0 a
Heuser 1979 [28] 32 14 10.6 b 3.6 – 31.0 a
Von Fournier 1980 [29] 100 17 6.6 b 2.1 – 20.6 c
Galante 1981 [30] 196 N/A 2.0 N/A
Tabbane 1989 [31] 75 N/A 3.8 0.5 – 25.3 a
Kuroishi 1990 [32] 142 N/A 5.7 b 0.4 – 42.4 a
Spratt 1993 [19] 448 9 8.5 5.0 – 15.7 d
Peer 1993 [33] 236 >10 5.0 1.5 – 17.1 e
Tilanus-Linthorst 2005 [34] 47 12 2.0 b 0.4 – 18.6 a
Weedon-Felkjaer 2008 [35] 969 15 3.1 1.0 – 9.6 d
Millet 2011 [36] 37 9 11.2 b −222.9 – 146.6 a
  1. N/A: not available, a minimum-maximum, b mean, c 2.5-97.5 percentile, d 25-75 percentile, e 68% confidence interval.