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Table 3 Multivariate logistic regression analysis of individual blood miRNA and miRNA classifier of miR-193a-3p, miR-23a and miR-338-5p

From: Potentiality of a triple microRNA classifier: miR-193a-3p, miR-23a and miR-338-5p for early detection of colorectal cancer

Statistical parameters miR-193a-3p miR-23a miR-338-5p miR-193a-3p + miR-23a miR-193a-3p + miR-338-5p miR-23a + miR-338-5p miR-193a-3p + miR-23a + miR-338-5p
AUC 0.852 0.787 0.871 0.852 0.872 0.873 0.887
95% CI 0.768 - 0.935 0.685 - 0.889 0.800 - 0.942 0.770 - 0.935 0.798 - 0.946 0.803 - 0.942 0.821 - 0.953
Sensitivity (%) 100.0 94.3 81.4 74.3 94.3 81.4 80.0
Specificity (%) 56.2 53.1 75.0 81.2 65.6 75.0 84.4
Accuracy (%) 83.3 81.4 83.3 83.3 83.3 82.4 83.3
Youden’s Indexa 0.562 0.474 0.564 0.555 0.599 0.564 0.644
Cut-off value 0.346 0.502 0.640 0.745 0.474 0.636 0.728
  1. aYouden’s Index = sensitivity + specificity - 1.