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Table 3 Association between total alcohol and wine intake and histological types* of ovarian carcinoma, OCAC studies

From: Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium

Intake/d

Controls N=10,358

High-Grade Serous N=2,580

Mucinous N=245

Endometrioid N=506

Clear Cell N=501

Low-Grade Serous N=198

 
 

Co

Ca

OR (95% CI)

Ca

OR (95% CI)

Ca

OR (95% CI)

Ca

OR (95% CI)

Ca

OR (95% CI)

P value†

Total alcohol ‡

            

 None

4,296

1,060

1.0 (Ref)

98

1.0 (Ref)

214

1.0 (Ref)

223

1.0 (Ref)

61

1.0 (Ref)

 

 Up to 1 drink

3,928

1,029

0.95 (0.84-1.07)

97

1.08 (0.76-1.52)

207

0.97 (0.76-1.23)

188

0.84 (0.66-1.07)

90

0.95 (0.65-1.38)

 

 1-2 drinks

1,112

282

0.97 (0.83-1.15)

26

1.08 (0.66-1.75)

50

0.96 (0.68-1.36)

53

0.97 (0.69-1.37)

29

1.28 (0.78-2.11)

 

 2-3 drinks

400

79

0.78 (0.60-1.02)

11

1.36 (0.69-2.67)

23

1.36 (0.85-2.19)

17

0.96 (0.56-1.63)

8

0.98 (0.45-2.13)

 

 >3 drinks

622

130

0.96 (0.77-1.20)

13

0.98 (0.52-1.82)

12

0.49 (0.27-0.91)

20

0.82 (0.50-1.34)

10

1.12 (0.55-2.29)

 

P trend

  

0.31

 

0.71

 

0.25

 

0.50

 

0.54

0.67

 >2 drinks§

1,022

209

0.88 (0.74-1.06)

24

1.12 (0.69-1.83)

35

0.85 (0.58-1.26)

37

0.88 (0.60-1.30)

18

1.05 (0.59-1.86)

 

P trend §

  

0.24

 

0.62

 

0.45

 

0.52

 

0.53

0.71

Wine

            

 None

5,307

1,316

1.0 (Ref)

128

1.0 (Ref)

263

1.0 (Ref)

272

1.0 (Ref)

81

1.0 (Ref)

 

 Up to 4 oz

3,984

1,022

0.93 (0.83-1.04)

103

1.12 (0.81-1.54)

206

0.96 (0.77-1.21)

195

0.87 (0.69-1.09)

91

0.94 (0.66-1.34)

 

 4-8 oz

522

129

0.93 (0.75-1.16)

10

1.03 (0.52-2.04)

22

0.98 (0.61-1.58)

24

0.95 (0.60-1.50)

13

1.33 (0.70-2.50)

 

 >8 oz

545

113

0.86 (0.68-1.09)

4

0.39 (0.14-1.09)

15

0.68 (0.39-1.20)

10

0.43 (0.22-0.83)

13

1.35 (0.71-2.56)

 

P trend

  

0.13

 

0.32

 

0.29

 

0.02

 

0.34

0.09

 >4 oz §

1,067

242

0.89 (0.75-1.06)

14

0.70 (0.39-1.27)

37

0.84 (0.57-1.23)

34

0.70 (0.47-1.03)

26

1.34 (0.81-2.20)

 

P trend §

  

0.13

 

0.61

 

0.41

 

0.05

 

0.44

0.25

  1. Adjusted for age (<40; 40-49; 50-59; 60-69; 70+ years), smoking status (never, former, current), site (AUS, CON, DOV, GER, HAW, HOP, MAL, NCO, NEC, NJO, POL, SON), race/ethnicity (white nonHispanic; white Hispanic; black non Hispanic; Asian; other or unknown); menopausal status (pre/peri-menopausal; postmenopausal, unknown or missing), oral contraceptive use (<6mo, 6-22 mo, 23+ mo, unknown or missing), tubal ligation (yes; no; unknown or missing), endometriosis (yes; no; unknown or missing), hysterectomy (yes; no; unknown or missing), family history of breast or ovarian cancer in first-degree relatives (no; yes; unknown; no daughters or sisters), parity/age at last birth (nulliparous; 1-2 births/age ≤25 yrs at last pregnancy; 3+ births/age ≤25 yrs at last pregnancy; 1-2 births/age >25 years at last pregnancy; 3+ births/age >25 years at last pregnancy; yes if ever pregnant but unknown or missing age at last pregnancy age; no or unknown if ever pregnant and missing age at last pregnancy, interview year (1990-1994; 1995-1999; 2000-2004; 2005-2009; missing), age at menarche (8-10 yrs; 11 yrs; 12 yrs; 13 yrs; 14-21 yrs; <8 or ≥ 22 yrs), body mass index (continuous) and education (less than high school, high school, some college, completed college or university, completed graduate or professional degree, missing).
  2. * Cases restricted to samples with information on grade for serous, mucinous and endometrioid histologic types, and for whom we applied the algorithm to reduce histologic misclassification (see Methods).
  3. † P for tumor heterogeneity derived from testing the trend variable for alcohol or wine intake in polytomous regression models with 5 df (see Statistical analysis).
  4. ‡ 1 drink = 10 grams ethanol.
  5. § Risk estimates and P trend values are from models that collapse the two highest intake categories.
  6. Models are also simultaneously adjusted for consumption of beer and liquor intake.
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BMC Cancer

ISSN: 1471-2407

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