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Table 3 Association between total alcohol and wine intake and histological types* of ovarian carcinoma, OCAC studies

From: Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium

Intake/d Controls N=10,358 High-Grade Serous N=2,580 Mucinous N=245 Endometrioid N=506 Clear Cell N=501 Low-Grade Serous N=198  
  Co Ca OR (95% CI) Ca OR (95% CI) Ca OR (95% CI) Ca OR (95% CI) Ca OR (95% CI) P value†
Total alcohol            
 None 4,296 1,060 1.0 (Ref) 98 1.0 (Ref) 214 1.0 (Ref) 223 1.0 (Ref) 61 1.0 (Ref)  
 Up to 1 drink 3,928 1,029 0.95 (0.84-1.07) 97 1.08 (0.76-1.52) 207 0.97 (0.76-1.23) 188 0.84 (0.66-1.07) 90 0.95 (0.65-1.38)  
 1-2 drinks 1,112 282 0.97 (0.83-1.15) 26 1.08 (0.66-1.75) 50 0.96 (0.68-1.36) 53 0.97 (0.69-1.37) 29 1.28 (0.78-2.11)  
 2-3 drinks 400 79 0.78 (0.60-1.02) 11 1.36 (0.69-2.67) 23 1.36 (0.85-2.19) 17 0.96 (0.56-1.63) 8 0.98 (0.45-2.13)  
 >3 drinks 622 130 0.96 (0.77-1.20) 13 0.98 (0.52-1.82) 12 0.49 (0.27-0.91) 20 0.82 (0.50-1.34) 10 1.12 (0.55-2.29)  
P trend    0.31   0.71   0.25   0.50   0.54 0.67
 >2 drinks§ 1,022 209 0.88 (0.74-1.06) 24 1.12 (0.69-1.83) 35 0.85 (0.58-1.26) 37 0.88 (0.60-1.30) 18 1.05 (0.59-1.86)  
P trend §    0.24   0.62   0.45   0.52   0.53 0.71
Wine             
 None 5,307 1,316 1.0 (Ref) 128 1.0 (Ref) 263 1.0 (Ref) 272 1.0 (Ref) 81 1.0 (Ref)  
 Up to 4 oz 3,984 1,022 0.93 (0.83-1.04) 103 1.12 (0.81-1.54) 206 0.96 (0.77-1.21) 195 0.87 (0.69-1.09) 91 0.94 (0.66-1.34)  
 4-8 oz 522 129 0.93 (0.75-1.16) 10 1.03 (0.52-2.04) 22 0.98 (0.61-1.58) 24 0.95 (0.60-1.50) 13 1.33 (0.70-2.50)  
 >8 oz 545 113 0.86 (0.68-1.09) 4 0.39 (0.14-1.09) 15 0.68 (0.39-1.20) 10 0.43 (0.22-0.83) 13 1.35 (0.71-2.56)  
P trend    0.13   0.32   0.29   0.02   0.34 0.09
 >4 oz § 1,067 242 0.89 (0.75-1.06) 14 0.70 (0.39-1.27) 37 0.84 (0.57-1.23) 34 0.70 (0.47-1.03) 26 1.34 (0.81-2.20)  
P trend §    0.13   0.61   0.41   0.05   0.44 0.25
  1. Adjusted for age (<40; 40-49; 50-59; 60-69; 70+ years), smoking status (never, former, current), site (AUS, CON, DOV, GER, HAW, HOP, MAL, NCO, NEC, NJO, POL, SON), race/ethnicity (white nonHispanic; white Hispanic; black non Hispanic; Asian; other or unknown); menopausal status (pre/peri-menopausal; postmenopausal, unknown or missing), oral contraceptive use (<6mo, 6-22 mo, 23+ mo, unknown or missing), tubal ligation (yes; no; unknown or missing), endometriosis (yes; no; unknown or missing), hysterectomy (yes; no; unknown or missing), family history of breast or ovarian cancer in first-degree relatives (no; yes; unknown; no daughters or sisters), parity/age at last birth (nulliparous; 1-2 births/age ≤25 yrs at last pregnancy; 3+ births/age ≤25 yrs at last pregnancy; 1-2 births/age >25 years at last pregnancy; 3+ births/age >25 years at last pregnancy; yes if ever pregnant but unknown or missing age at last pregnancy age; no or unknown if ever pregnant and missing age at last pregnancy, interview year (1990-1994; 1995-1999; 2000-2004; 2005-2009; missing), age at menarche (8-10 yrs; 11 yrs; 12 yrs; 13 yrs; 14-21 yrs; <8 or ≥ 22 yrs), body mass index (continuous) and education (less than high school, high school, some college, completed college or university, completed graduate or professional degree, missing).
  2. * Cases restricted to samples with information on grade for serous, mucinous and endometrioid histologic types, and for whom we applied the algorithm to reduce histologic misclassification (see Methods).
  3. P for tumor heterogeneity derived from testing the trend variable for alcohol or wine intake in polytomous regression models with 5 df (see Statistical analysis).
  4. ‡ 1 drink = 10 grams ethanol.
  5. § Risk estimates and P trend values are from models that collapse the two highest intake categories.
  6. Models are also simultaneously adjusted for consumption of beer and liquor intake.