Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium

Kelemen, Linda E; Bandera, Elisa V; Terry, Kathryn L; Rossing, Mary Anne; Brinton, Louise A; Doherty, Jennifer A; Ness, Roberta B; Kjær, Susanne Krüger; Chang-Claude, Jenny; Köbel, Martin; Lurie, Galina; Thompson, Pamela J; Carney, Michael E; Moysich, Kirsten; Edwards, Robert; Bunker, Clare; Jensen, Allan; Høgdall, Estrid; Cramer, Daniel W; Vitonis, Allison F; Olson, Sara H; King, Melony; Chandran, Urmila; Lissowska, Jolanta; Garcia-Closas, Montserrat; Yang, Hannah; Webb, Penelope M; Schildkraut, Joellen M; Goodman, Marc T; Risch, Harvey A

doi:10.1186/1471-2407-13-28

Table 1 Overview of OCAC studies

From: Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium

Study acronym	Study name	Controls, n	Cases, n						White non-Hispanic %^*	Carcinoma cases with grade information %†	Recruitment year and location	Matching variables‡
			Border-line	All carcinomas§	Serous	Muc-inous	Endo-metrioid	Clear Cell
AUS [59]	AOCS (Australian Ovarian Cancer Study) and ACS (Australian Cancer Study – Ovarian Cancer)	1,333	259	882	537	39	106	71	93.3	92.8	2002-2006; Australia	State of residence and 5-year age groups
CON [43]	CON (Connecticut Ovarian Cancer Study)	526	103	339	193	18	70	33	91.7	85.4	1998-2003; Connecticut, USA	3 age strata (35-49, 50-64 and 65-79 years)
DOV [44]	DOVE (Diseases of the Ovary and their Evaluation)	1,116	189	483	269	20	81	31	90.9	82.7	2002-2005 and 2006-2009; Washington, USA	5-year age groups, 1-year calendar intervals and two county strata
GER [54]	GOCS (German Ovarian Cancer Study)	502	30	209	107	24	23	6	99.9	100	1993-1996; Germany	Age and study region
HAW [45]	HAWAII (Hawaii Ovarian Cancer Study)	1,100	97	384	176	42	68	50	31.9	91.3	1993-2008; Hawaii, USA	5-year age groups and race
HOP [46]	HOPE (Hormones and Ovarian Cancer Prediction Study)	1,365	76	530	289	27	71	46	96.0	94.1	2003-2009; Pennsylvania, USA	5-year age groups and area code plus 3 number prefix
MAL [55–57]	MALOVA (Malignant Ovarian Cancer Study)	908	115	267	157	30	41	21	100	93.9	1994-1999; Denmark	5-year age groups
NCO [47, 48]	NCOCS (North Carolina Ovarian Cancer Study)	979	212	777	429	44	126	82	80.9	100	1999-2008; North Carolina, USA	5-year age groups and race
NEC [49, 50]	NECC (New England-based Case-Control Study)	1,109	274	707	386	47	152	96	96.3	100	1992-1997 and 1998-2003; New England, USA	5-year age groups and region of residence
NJO [51, 52]	NJOCS (New Jersey Ovarian Cancer Study)	277	0	183	104	7	30	24	87.6	87.2	2002-2008; New Jersey, USA	None
POL [58]	POL (Polish Ovarian Cancer Control Study)	601	18	236	101	25	52	13	100	66.3	2000-2003; Poland	5-year age groups and study center
SON [53]	SON (Southern Ontario Study of Reproduction, Diet and Health)	542	82	345	200	38	65	28	98.3	0	1989-1992; Southern Ontario	3 age strata (35-49, 50-64 and 65-79 years)
Totals		10,358	1,455	5,342	2,948	361	885	501	87.7	84.86

* White non-Hispanic subjects as a percentage of all race-ethnicities enrolled in each study.
† Percentages reflect grade available for serous, mucinous and endometrioid carcinomas and for which we applied the algorithm to reduce histologic misclassification (see Methods).
‡ All studies except GER used frequency matching.
§ Includes the epithelial histologic types: serous, mucinous, endometrioid, clear cell, mixed epithelial, transitional cell, squamous cell, and undifferentiated.

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ISSN: 1471-2407

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