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Table 1 Baseline patient and tumor characteristics

From: Clinical outcome, proteome kinetics and angiogenic factors in serum after thermoablation of colorectal liver metastases

Clinicopathological characteristics

CSA

RFA

PH

Unresectable

p-value

n

20

22

134

29

 

Median age (years)

66.7

60.0

62.3

60.8

0.151

  (IQR)

(9.3)

(16.7)

(13.8)

(17.4)

 

Sex

    

0.392

  Female

10 (50%)

10 (45%)

55 (41%)

8 (28%)

 

  Male

10 (50%)

12 (55%)

79 (59%)

21(72%)

 

Site of primary tumor

    

0.732

  Colon

12 (60%)

15 (68%)

84 (63%)

21(72%)

 

  Rectum

8 (40%)

7 (32%)

50 (37%)

8 (28%)

 

Synchronous: metachronous liver metastasis

4:16

10:12

44:90

14:15

0.136

Interval resection of primary tumor and detection liver metastasis

    

0.385

  ≤12 months

9 (45%)

14 (64%)

88 (66%)

20 (69%)

 

  >12 months

11(55%)

8 (36%)

46 (34%)

9 (31%)

 

Node status of primary tumor

    

0.479

  Negative

8 (40%)

6 (27%)

50 (37%)

7 (24%)

 

  Positive

12 (60%)

16 (63%)

84 (63%)

22 (76%)

 

Adjuvant chemotherapy after primary

    

0.470

  No

12 (60%)

12 (55%)

92 (69%)

21 (72%)

 

  Yes

8 (40%)

10 (45%)

42 (31%)

8 (28%)

 

Size largest metastasis (cm)

     

  Median (IQR)

4.0 (2.0)

3.0 (2.0)

5.0 (4.5)

3.5 (4.0)*

0.440

Number of liver metastases

    

<0.0001

  1

10 (50%)

6 (27%)

86 (64%)

6 (21%)

 

  >1

10 (50%)

16 (63%)

48 (36%)

19 (66%) γ

 

Preoperative CEA (μg/L)

     

  Median (IQR)

21.2 (64.8)

12.0 (57.0)

22.5(71.4)$

20.0 (116.3)&

0.623

CRS

    

0.009

  ≤2

15(75%)

10 (46%)

89 (66%)

  

  >2

5 (25%)

12 (55%)

45 (34%)

  

Surgical procedure

    

<0.0001

  No resection

13 (65%)

11 (50%)

-

29 (100%)

 

  < Hemihepatectomy

6 (30%)

7 (32%)

36 (27%)

  

  Hemihepatectomy

1 (5%)

3 (14%)

56 (42%)

  

  Extended

-

1 (5%)

42 (31%)

  

  Hemihepatectomy

     
  1. *5 missing.
  2. γ 4 missing.
  3. $ 9 missing.
  4. & 2 missing.
  5. CSA, Cryosurgical ablation.
  6. RFA, Radiofrequency ablation.
  7. PH, Partial hepatectomy.
  8. CEA, Carcinoembryonic antigen.
  9. CRS, Clinical risk score.