CT-RT | RT-EGFRinhibitors | ||||
---|---|---|---|---|---|
Patient/Tumour Data | No. | % | No. | % | p |
Nº of patients | 56 | 52 | |||
Age, years | |||||
Median | 58 | 60 | NS | ||
Range | 44-74 | 33-84 | |||
Sex | |||||
Male | 55 | 98 | 46 | 89 | 0.05 |
Female | 1 | 2 | 6 | 11 | |
Current smokers | |||||
No | 3 | 5 | 3 | 6 | NS |
Yes | 28 | 50 | 49 | 94 | |
Unknown | 25 | 45 | 0 | 0 | |
Alcohol consumption | |||||
No | 1 | 2 | 12 | 23 | |
Yes | 28 | 50 | 39 | 75 | 0.02 |
Unknown | 27 | 48 | 1 | 2 | |
Performance status | |||||
ECOG 0–1 | 51 | 91 | 45 | 87 | NS |
ECOG 2-3 | 5 | 9 | 7 | 13 | |
Tumor site | |||||
Oral cavity | 13 | 23 | 3 | 6 | |
Oropharynx | 16 | 29 | 23 | 44 | 0.02 |
Larynx | 17 | 30 | 21 | 40 | |
Hypopharynx | 10 | 18 | 5 | 10 | |
Grade | |||||
Well/Moderate | 34 | 61 | 12 | 23 | NS |
Poor | 5 | 9 | 6 | 12 | |
Unknown | 17 | 30 | 34 | 65 | |
Tumour stage | |||||
T1-T3 | 20 | 36 | 30 | 58 | NS |
T4 | 36 | 64 | 22 | 42 | |
Nodal status | |||||
N0-N1 | 24 | 43 | 32 | 61 | NS |
N2-N3 | 32 | 57 | 20 | 39 | |
P16 expression | |||||
negative | 46 | 82 | 44 | 85 | NS |
positive | 10 | 18 | 8 | 15 | |
HPV16 expression | |||||
negative | 50 | 89 | 46 | 88 | NS |
positive | 6 | 11 | 6 | 12 | |
Irradiation dose | 71.2 | 71 | NS | ||
Mean | 57-72 | 70-78 | |||
Range | |||||
Type of radiotherapy | |||||
Conventional RT | 1 | 2 | 10 | 19 | 0.003 |
Concomitant boost | 55 | 92 | 42 | 81 | |
Response | |||||
Complete response | 42 | 75 | 41 | 79 | |
Partial response | 8 | 14 | 8 | 15 | NS |
Stable disease | 2 | 4 | 0 | 0 | |
Progression | 1 | 2 | 0 | 0 | |
Unknown | 3 | 5 | 3 | 6 |