Figure 8

Loss of p63 expression in basal cells detected by chromogrn-based immunostaing. Human prostate tissue sections were double immunostained for CK 34βE12 plus p63. Note that a majority of basal cells in non-disrupted layers have the expression of CK 34βE12 plus p63 (arrowheads), whereas nearly all those cells near the focally disrupted (circles) layers are devoid expression of tumor suppressor p63 (arrows). A and C: 200X. B and D. A higher (500X) of A and C, respectively.