From: Inorganic phosphate and the risk of cancer in the Swedish AMORIS study
Cancer site (ICD-7) | n cases | Quartiles of Pi (mmol/L), HR (95% CI) | P-value for trend | Standardized Pi, HR (95% CI) | |||
---|---|---|---|---|---|---|---|
< 0.99 | 0.99 – 1.09 | 1.09 – 1.19 | ≥ 1.19 | ||||
Lip, oral cavity, pharynx (140–149) | 66 | 1.00 (Ref) | 0.62 (0.30 – 1.29) | 0.93 (0.48 – 1.81) | 1.05 (0.55 – 2.00) | 0.67 | 1.04 (0.80 – 1.35) |
Oesophagus (150) | 75 | 1.00 (Ref) | 0.57 (0.25 – 1.30) | 1.56 (0.81 – 2.99) | 1.95 (1.04 – 3.67) | 0.004 | 1.34 (1.10 – 1.65) |
Stomach (151) | 251 | 1.00 (Ref) | 1.71 (1.18 – 2.47) | 1.48 (1.01 – 2.18) | 1.52 (1.03 – 2.25) | 0.10 | 1.13 (0.98 – 1.29) |
Colorectal (153, 154) | 1410 | 1.00 (Ref) | 1.06 (0.91 – 1.23) | 1.04 (0.89 – 1.21) | 1.11 (0.96 – 1.30) | 0.22 | 1.06 (1.00 – 1.12) |
Liver, gallbladder (155) | 260 | 1.00 (Ref) | 1.08 (0.75 – 1.55) | 1.38 (0.97 – 1.95) | 1.26 (0.88 – 1.81) | 0.11 | 1.09 (0.95 – 1.25) |
Pancreas (157) | 335 | 1.00 (Ref) | 1.08 (0.80 – 1.46) | 0.93 (0.67 – 1.28) | 1.24 (0.92 – 1.68) | 0.28 | 1.04 (0.93 – 1.18) |
Larynx (161) | 16 | 1.00 (Ref) | 2.86 (0.30 – 27.58) | 7.31 (0.90 – 59.67) | 5.72 (0.66 – 49.37) | 0.05 | 1.36 (0.85 – 2.17) |
Lung (162) | 887 | 1.00 (Ref) | 1.21 (0.98 – 1.48) | 1.51 (1.24 – 1.84) | 1.66 (1.37 – 2.02) | < 0.0001 | 1.20 (1.12 – 1.29) |
Breast (170) | 4925 | 1.00 (Ref) | 0.94 (0.87 – 1.01) | 0.89 (0.82 – 0.96) | 0.81 (0.75 – 0.88) | < 0.0001 | 0.93 (0.90 – 0.96) |
Cervix uteri (171) | 318 | 1.00 (Ref) | 1.12 (0.82 – 1.53) | 1.09 (0.80 – 1.51) | 1.12 (0.82 – 1.54) | 0.52 | 1.03 (0.91 – 1.16) |
Endometrium (172) | 900 | 1.00 (Ref) | 0.83 (0.70 – 0.99) | 0.72 (0.60 – 0.87) | 0.72 (0.60 – 0.87) | 0.0002 | 0.84 (0.78 – 0.91) |
Ovary (175) | 637 | 1.00 (Ref) | 1.00 (0.81 – 1.24) | 0.97 (0.78 – 1.20) | 0.90 (0.72 – 1.13) | 0.31 | 0.98 (0.90 – 1.07) |
Other parts of uterus (174, 176) | 67 | 1.00 (Ref) | 0.81 (0.39 – 1.71) | 1.37 (0.71 – 2.67) | 1.15 (0.58 – 2.29) | 0.39 | 1.07 (0.83 – 1.38) |
Kidney (180) | 262 | 1.00 (Ref) | 1.19 (0.85 – 1.68) | 1.24 (0.88 – 1.75) | 1.04 (0.72 – 1.49) | 0.81 | 1.02 (0.89 – 1.16) |
Bladder (181) | 325 | 1.00 (Ref) | 1.05 (0.77 – 1.43) | 1.11 (0.82 – 1.52) | 1.02 (0.74 – 1.40) | 0.79 | 1.02 (0.91 – 1.16) |
Melanoma of skin (190) | 532 | 1.00 (Ref) | 1.02 (0.80 – 1.29) | 1.09 (0.86 – 1.39) | 0.99 (0.77 – 1.27) | 0.93 | 1.05 (0.95 – 1.15) |
Nonmelanoma of skin (191) | 442 | 1.00 (Ref) | 1.47 (1.12 – 1.94) | 1.33 (1.00 – 1.77) | 1.53 (1.16 – 2.04) | 0.01 | 1.12 (1.01 – 1.24) |
Brain/central nervous system (193) | 456 | 1.00 (Ref) | 0.90 (0.70 – 1.17) | 1.00 (0.78 – 1.30) | 0.95 (0.73 – 1.24) | 0.88 | 1.00 (0.90 – 1.11) |
Thyroid gland (194) | 121 | 1.00 (Ref) | 0.77 (0.45 – 1.30) | 1.14 (0.70 – 1.85) | 0.99 (0.60 – 1.63) | 0.65 | 1.06 (0.88 – 1.27) |
Other endocrine organ (195) | 407 | 1.00 (Ref) | 0.33 (0.25 – 0.43) | 0.15 (0.11 – 0.43) | 0.19 (0.14 – 0.26) | < 0.0001 | 0.45 (0.41 – 0.51) |
Bone (196) | 1080 | 1.00 (Ref) | 1.21 (1.02 – 1.44) | 1.20 (1.01 – 1.43) | 1.19 (1.00 – 1.42) | 0.06 | 1.08 (1.02 – 1.16) |
Soft tissues (197) | 93 | 1.00 (Ref) | 0.84 (0.48 – 1.47) | 0.79 (0.44 – 1.41) | 1.02 (0.58 – 1.78) | 0.96 | 1.02 (0.82 – 1.29) |
Non-Hodgkin’s lymphoma (200, 202) | 419 | 1.00 (Ref) | 0.96 (0.74 – 1.24) | 0.95 (0.72 – 1.24) | 0.88 (0.67 – 1.16) | 0.38 | 1.00 (0.90 – 1.11) |
Hodgkin’s lymphoma (201) | 39 | 1.00 (Ref) | 1.23 (0.62 – 2.43) | 1.38 (0.70 – 2.75) | 0.63 (0.27 – 1.48) | 0.94 | 1.18 (0.86 – 1.62) |
Multiple myeloma (203) | 140 | 1.00 (Ref) | 1.31 (0.82 – 2.10) | 1.26 (0.78 – 2.04) | 1.14 (0.69 – 1.88) | 0.70 | 1.02 (0.84 – 1.22) |
Leukemia (204–207) | 265 | 1.00 (Ref) | 0.74 (0.51 – 1.06) | 0.94 (0.67 – 1.32) | 1.26 (0.91 – 1.74) | 0.07 | 1.09 (0.95 – 1.24) |
Other cancer 1 | 720 | 1.00 (Ref) | 1.14 (0.92 – 1.40) | 1.05 (0.84 – 1.30) | 1.20 (0.97 – 1.49) | 0.17 | 1.08 (0.99 – 1.17) |