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Table 3 Hazard ratios and 95% confidence intervals for the risk of site-specific cancer for quartiles of serum Pi in men

From: Inorganic phosphate and the risk of cancer in the Swedish AMORIS study

Cancer site (ICD-7)

n cases

Quartiles of Pi (mmol/L), HR (95% CI)

P-value for trend

Standardized Pi, HR (95% CI)

< 0.92

0.92 – 1.03

1.03 – 1.14

≥ 1.14

Lip, oral cavity, pharynx (140–149)

135

1.00 (Ref)

1.12 (0.71 – 1.77)

1.15 (0.71 – 1.86)

1.28 (0.77 – 2.12)

0.31

1.10 (0.93 – 1.30)

Oesophagus (150)

196

1.00 (Ref)

1.23 (0.84 – 1.80)

1.26 (0.84 – 1.89)

1.43 (0.94 – 2.18)

0.17

1.12 (0.98 – 1.28)

Stomach (151)

400

1.00 (Ref)

1.10 (0.87 – 1.41)

0.80 (0.60 – 1.07)

1.07 (0.80 – 1.44)

0.49

0.98 (0.88 – 1.09)

Colorectal (153, 154)

1929

1.00 (Ref)

1.06 (0.94 – 1.18)

0.95 (0.84 – 1.08)

0.91 (0.79 – 1.05)

0.07

0.95 (0.91 – 1.00)

Liver, gallbladder (155)

319

1.00 (Ref)

1.15 (0.86 – 1.54)

1.07 (0.78 – 1.47)

1.38 (1.00 – 1.91)

0.14

1.09 (0.98 – 1.22)

Pancreas (157)

427

1.00 (Ref)

1.32 (1.03 – 1.71)

1.27 (0.97 – 1.68)

1.41 (1.05 – 1.88)

0.02

1.11 (1.02 – 1.22)

Larynx (161)

143

1.00 (Ref)

1.13 (0.72 – 1.77)

1.33 (0.84 – 2.10)

1.28 (0.78 – 2.10)

0.24

1.11 (0.95 – 1.29)

Lung (162)

1396

1.00 (Ref)

1.24 (1.07 – 1.42)

1.22 (1.05 – 1.42)

1.35 (1.15 – 1.58)

0.002

1.10 (1.04 – 1.15)

Prostate (177)

5075

1.00 (Ref)

1.01 (0.94 – 1.08)

1.02 (0.94 – 1.10)

0.98 (0.90 – 1.07)

0.72

0.98 (0.95 – 1.01)

Testis (178)

159

1.00 (Ref)

0.98 (0.60 – 1.58)

0.97 (0.60 – 1.57)

1.11 (0.70 – 1.75)

0.62

1.02 (0.88 – 1.19)

Kidney (180)

525

1.00 (Ref)

1.05 (0.84 – 1.32)

1.14 (0.90 – 1.44)

0.87 (0.66 – 1.15)

0.49

1.03 (0.94 – 1.13)

Bladder (181)

1181

1.00 (Ref)

0.99 (0.85 – 1.15)

1.04 (0.89 – 1.21)

1.02 (0.86 – 1.21)

0.76

1.02 (0.96 – 1.08)

Melanoma of skin (190)

765

1.00 (Ref)

1.02 (0.85 – 1.24)

1.08 (0.89 – 1.32)

1.01 (0.89 – 1.25)

0.66

1.01 (0.94 – 1.09)

Nonmelanoma of skin (191)

772

1.00 (Ref)

0.95 (0.80 – 1.14)

0.90 (0.74 – 1.10)

1.13 (0.91 – 1.39)

0.46

0.98 (0.91 – 1.06)

Brain/central nervous system (193)

527

1.00 (Ref)

1.03 (0.82 – 1.31)

1.08 (0.84 – 1.37)

1.06 (0.82 – 1.37)

0.74

1.01 (0.92 – 1.10)

Thyroid gland (194)

69

1.00 (Ref)

0.94 (0.45 – 1.98)

1.76 (0.90 – 3.43)

1.69 (0.85 – 3.38)

0.04

1.15 (0.93 – 1.41)

Other endocrine organ (195)

215

1.00 (Ref)

0.46 (0.31 – 0.66)

0.44 (0.29 – 0.65)

0.67 (0.47 – 0.96)

0.03

0.87 (0.76 – 1.00)

Bone (196)

1690

1.00 (Ref)

1.15 (1.02 – 1.31)

1.15 (1.01 – 1.32)

1.25 (1.08 – 1.10)

0.002

1.06 (1.01 – 1.11)

Soft tissues (197)

126

1.00 (Ref)

1.48 (0.93 – 2.37)

1.13 (0.67 – 1.92)

1.42 (0.83 – 2.42)

0.32

1.11 (0.95 – 1.30)

Non-Hodgkin’s lymphoma (200, 202)

613

1.00 (Ref)

1.24 (1.00 – 1.52)

1.06 (0.84 – 1.33)

1.22 (0.96 – 1.55)

0.25

1.08 (1.00 – 1.17)

Hodgkin’s lymphoma (201)

62

1.00 (Ref)

0.98 (0.82 – 1.18)

1.01 (0.99 – 1.02)

1.45 (0.95 – 2.22)

0.51

0.92 (0.71 – 1.20)

Multiple myeloma (203)

259

1.00 (Ref)

1.31 (0.96 – 1.77)

0.84 (0.57 – 1.21)

1.20 (0.83 – 1.74)

0.82

1.02 (0.90 – 1.16)

Leukemia (204–207)

398

1.00 (Ref)

0.88 (0.68 – 1.13)

0.79 (0.59 – 1.04)

0.85 (0.63 – 1.14)

0.12

0.98 (0.89 – 1.09)

Other cancer 1

865

1.00 (Ref)

1.15 (0.96 – 1.38)

1.23 (1.02 – 1.49)

1.38 (1.13 – 1.68)

0.003

1.10 (1.03 – 1.18)

  1. All models were adjusted for age, SES, fasting status, calcium, alkaline phosphatase, glucose, creatinine, season, history of diabetes and lung diseases.
  2. 1Other cancer than the separately presented sites.
  3. ICD-7, International Classification of Diseases, seventh revision; ref, referent group.
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