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Table 2 Hazard ratios and 95% confidence intervals for the risk of overall cancer for quartiles and standardized values of serum Pi levels

From: Inorganic phosphate and the risk of cancer in the Swedish AMORIS study

 

Overall cancer

Overall cancer1

 

Hazard ratio (95%CI)

Hazard ratio (95%CI)

Men and women combined

  

Standardized Pi (SD = 0.17)

0.97 (0.96 – 0.99)

0.98 (0.96 – 0.99)

Quartiles of Pi (mmol/L)

  

< 0.95

1.00 (Ref)

1.00 (Ref)

0.95 – 1.05

0.98 (0.96 – 1.02)

1.00 (0.97 – 1.03)

1.05 – 1.16

0.94 (0.91 – 0.97)

0.95 (0.91 – 0.98)

≥ 1.16

0.94 (0.91 – 0.97)

0.95 (0.92 – 0.98)

P-value for trend

< 0.0001

< 0.0001

Men 2

  

Standardized Pi (SD = 0.17)

1.02 (1.00 – 1.04)

1.02 (1.00 – 1.04)

Quartiles of Pi (mmol/L)

  

< 0.92

1.00 (Ref)

1.00 (Ref)

0.92 – 1.03

1.06 (1.02 – 1.10)

1.05 (1.01 – 1.09)

1.03 – 1.14

1.04 (1.00 – 1.08)

1.03 (0.98 – 1.08)

≥ 1.14

1.07 (1.03 – 1.12)

1.06 (1.01 – 1.12)

P-value for trend

0.01

0.05

Women 2

  

Standardized Pi (SD = 0.16)

0.97 (0.96 – 0.99)

0.97 (0.95 – 0.99)

Quartiles of Pi (mmol/L)

  

< 0.99

1.00 (Ref)

1.00 (Ref)

0.99 – 1.09

0.95 (0.91 – 0.99)

0.98 (0.93 – 1.04)

1.09 – 1.19

0.93 (0.89 – 0.97)

0.93 (0.89 – 0.99)

≥ 1.19

0.91 (0.87 – 0.96)

0.93 (0.88 – 0.98)

P-value for trend

< 0.0001

0.001

  1. All models were adjusted for age, sex, SES, fasting status, calcium, alkaline phosphatase, glucose, creatinine, season, history of diabetes and lung diseases.
  2. 1A sensitivity analysis excluding the first three years of follow-up (n = 386,683).
  3. 2Not adjusted for sex.
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BMC Cancer

ISSN: 1471-2407

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