Figure 2

Comparative molecular analysis in Case 4 versus control. (A) Comparative analysis of the RNA editing levels at the GluR-B Q/R and R/G sites, GluR-6 I/V, Y/C and Q/R sites, GluR-5 Q/R site, Kv1.1 I/V, Gabra-3 I/M site and BLCAP Y/C, Q/R and K/R sites among normal white matter (WM, black), newly diagnosed (N, dark gray) and recurrent (R, light gray) tumor tissues of Case 4. The editing values are expressed as a percentage of the mean of three independent experiments. Error bars indicate standard error of the mean (S.E.M.), *p<0.05, **p<0.01. (B) A representative example of Ki-67 mRNA expression levels analysed by semi-quantitative RT-PCRs in the control (normal white matter), newly diagnosed and recurrent tumor samples of Case 4. (C) Densitometric analysis of Ki-67 mRNA expression is represented in arbitrary units calculated as a relative-fold increase in expression compared to the control arbitrarily set to 1. Each sample was normalized to β-actin mRNA. Error bars indicate standard error of the mean (S.E.M.) (n=3).