Figure 4

OGG1 inhibits oxidative DNA damage. DNA 8-OHdG levels in MCF-10A cells treated with E2 (50 nM) or vehicle for 48 h and in OGG1 knocked down MCF-10A cells are represented as a bar graph. ‘*’ and ‘#’ indicate p value <0.05 compared to vehicle-treated control and scrambled-transfected MCF-10A cells, respectively. ‘**’ indicates significant difference (p <0.05) between siOGG1 and siOGG1 + E2 groups.