Figure 5

Mitotic stability of the EGFP-HAC in HT1080 human cells treated by nine different drugs. A rate of HAC loss per generation was calculated as described in Methods and Figure 1. Blue bars correspond to the frequency of HAC loss when the cells were treated by taxol and its derivatives. The control corresponds to a frequency of spontaneous loss of the EGFP-HAC in human HT1080 cells.