Figure 4

Effects of siRNA-mediated inhibition of PDGFR-β expression on the growth of 3 MPNST cell lines. After 72 h transfection with 0.01, 0.02 and 0.05 pmol/μl siRNA, specific PDGFR-β knockdown was induced in all three cell lines. In the presence of 0.02 pmol/μl siRNA for PDGFR-β, cell proliferation was significantly inhibited compared with the control, in two MPNST cell lines, HS-Sch-2 (A) and FMS-1 (B), but not NMS-2PC (C). Data are the means ± SEM (n = 5). Similar results were obtained in at least two independent experiments. *P < 0.01 (by Student’s t-test).