Figure 1

The miRNA profile associated with paclitaxel-resistance and survival of OC patients. A, The heat map of miRNA microarray expression of SKOV3 and ST30 cells. The heat map diagram shows all the deregulated miRNAs passed T test. Each row represents a miRNA and each column represents a pair of samples (n=3). The color scale showmn at the top illustrates the relative expression level of a miRNA in the certain slide: red color represents a higher expression level than control sample; green color represents a lower expression level than the control sample. B, Realtime RT-PCR for miR-9, 155, 640 miR-320a, 22 and 129-5p in 45 serous ovarian adenocarcinoma FFPE tissues. The error bars represent SEM. The miRNAs are significantly deregulated in paclitaxel-resistant tissues compared with paclitaxel-sensitve tissues. (P=0.009, 0.027, 0.001, 0.019, 0.025 and 0.007 respectively).