Figure 3

Benign neoplasia and malignant lesions are targeted by AIs. A lung lesions were divided into three groups including hyperplasia, benign neoplasia and malignant as described [15]. Hyperplastic and benign neoplasia comprise majority of lesions in this model followed by malignant lesions. While percentage of hyperplastic lesions has not significantly changed in any of the AIs treatment, while PF-210 treatment significantly reduced the percentage of benign andenoma lesions. Axitinib and sunitinib also targeted benign adenoma lesions. All the AIs consistently targeted percentage of malignant lesions in the lungs. B Analysis of percentage of mice carrying each lesion in each treatment was consistent with the above finding. All the treated mice carried hyperplasia and, with the exception of PF-210, benign neoplasia lesions. Percentage of mice carrying malignant lesions was significantly reduced in all the mice treated with AIs. Asterisks indicate significant difference (p < 0.05) when comparing lesions in AI treated mice vs. corresponding vehicle-treated animals.