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Table 5 Agreement analysis of cobas EGFR mutation test (per lot) versussanger

From: Analytic performance studies and clinical reproducibility of a real-time PCRassay for the detection of epidermal growth factor receptor gene mutations informalin-fixed paraffin-embedded tissue specimens of non-small cell lungcancer

  

Sanger

  

Sanger

  

MD

MND

Total

  

MD

MND

Total

cobas EGFR test Lot 1

MD

69

2

71

cobas EGFR test Lot 2

MD

69

2

71

MND

3

78

81

MND

3

78

81

Total

72

80

152

Total

72

80

152

Positive agreement = 95.8% (95% CI: 88.3 to99.1%).

Positive agreement = 95.8% (95% CI: 88.3 to99.1%).

Negative agreement = 97.5% (95% CI: 91.3 to99.7%).

Negative agreement = 97.5% (95% CI: 91.3 to99.7%).

Overall agreement = 96.7% (95% CI: 92.5 to98.9%).

Overall agreement = 96.7% (95% CI: 92.5 to98.9%).

  1. CI, confidence interval; MD, mutation detected; MND, mutation notdetected.
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BMC Cancer

ISSN: 1471-2407

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