From: A pri-miR-218variant and risk of cervical carcinoma in Chinese women
Variables | rs11134527 | Adjusted OR* (95% CI) | P* | P** | rs2566 | Adjusted OR* (95% CI) | P* | P** | ||
---|---|---|---|---|---|---|---|---|---|---|
(cases/controls) | (cases/controls) | |||||||||
AA/AG | GG | CC/CT | TT | |||||||
Age, years | ||||||||||
≤46 (Mean) | 747/623 | 136/131 | 0.84 (0.64-1.11) | 0.215 | 0.364 | 774/669 | 109/85 | 1.02 (0.74-1.40) | 0.919 | 0.740 |
>46 (Mean) | 593/527 | 89/110 | 0.77 (0.56-1.06) | 0.111 | 602/564 | 80/73 | 1.00 (0.69-1.45) | 0.995 | ||
Age at primiparity, years | ||||||||||
≤24 (Mean) | 797/568 | 136/131 | 0.73 (0.56-0.96) | 0.022 | 0.452 | 822/625 | 111/74 | 1.12 (0.82-1.54) | 0.482 | 0.460 |
>24 (Mean) | 468/566 | 76/106 | 0.86 (0.62-1.20) | 0.386 | 481/591 | 63/81 | 0.91 (0.63-1.32) | 0.621 | ||
Menopausal status | ||||||||||
Premenopausal | 962/685 | 164/155 | 0.73 (0.57-0.94) | 0.013 | 0.425 | 986/743 | 140/97 | 1.00 (0.75-1.34) | 0.981 | 0.635 |
Postmenopausal | 366/463 | 61/86 | 0.90 (0.62-1.32) | 0.600 | 381/488 | 46/61 | 1.09 (0.70-1.70) | 0.696 | ||
BMI, kg/m 2 | ||||||||||
< 25 | 1026/759 | 175/157 | 0.79 (0.62-1.00) | 0.054 | 0.715 | 1061/810 | 140/106 | 1.00 (0.75-1.32) | 0.973 | 0.739 |
≥ 25 | 288/390 | 47/84 | 0.74 (0.50-1.12) | 0.152 | 295/422 | 40/52 | 1.02 (0.64-1.63) | 0.939 | ||
Histology | ||||||||||
CINIII | 129/1150 | 32/241 | 1.06 (0.68-1.66) | 0.789 | 0.169 | 137/1233 | 24/158 | 1.32 (0.80-2.16) | 0.274 | 0.409 |
SCC | 1068/1150 | 170/241 | 0.74 (0.59-0.92) | 0.008 | 1096/1233 | 142/158 | 0.95 (0.73-1.22) | 0.673 | ||
Non-squamous | 138/1150 | 23/241 | 0.75 (0.46-1.22) | 0.240 | 138/1233 | 23/158 | 1.18 (0.71-1.96) | 0.526 | ||
FIGO stage | ||||||||||
I | 633/1150 | 97/241 | 0.70 (0.53-0.91) | 0.008 | 0.796 | 645/1233 | 85/158 | 0.94 (0.70-1.27) | 0.689 | 0.341 |
II | 464/1150 | 75/241 | 0.72 (0.54-0.97) | 0.028 | 478/1233 | 61/158 | 0.96 (0.69-1.35) | 0.830 | ||
III~IV | 43/1150 | 5/241 | 0.43 (0.15-1.28) | 0.129 | 39/1233 | 9/158 | 1.97 (0.83-4.71) | 0.126 | ||
Tumor size, cm | ||||||||||
< 4 | 801/1150 | 139/241 | 0.78 (0.61-0.99) | 0.043 | 0.695 | 840/1233 | 100/158 | 0.88 (0.66-1.16) | 0.365 | 0.100 |
≥ 4 | 428/1150 | 69/241 | 0.71 (0.53-0.97) | 0.031 | 426/1233 | 71/158 | 1.25 (0.91-1.72) | 0.176 | ||
Pelvic LN | ||||||||||
Negative | 965/1150 | 174/241 | 0.83 (0.66-1.04) | 0.098 | 0.095 | 1002/1233 | 137/158 | 1.00 (0.77-1.29) | 0.970 | 0.819 |
Positive | 309/1150 | 39/241 | 0.55 (0.37-0.80) | 0.002 | 308/1233 | 40/158 | 0.96 (0.64-1.42) | 0.828 | ||
LVSI | ||||||||||
Negative | 750/1150 | 132/241 | 0.80 (0.63-1.02) | 0.073 | 0.305 | 783/1233 | 99/158 | 0.93 (0.70-1.24) | 0.632 | 0.379 |
Positive | 390/1150 | 56/241 | 0.64 (0.46-0.89) | 0.008 | 387/1233 | 59/158 | 1.06 (0.75-1.50) | 0.755 | ||
Depth of cervical stromal invasion | ||||||||||
≤ 1/2 | 584/1150 | 99/241 | 0.75 (0.57-0.98) | 0.037 | 0.898 | 598/1233 | 85/158 | 1.08 (0.81-1.45) | 0.602 | 0.709 |
> 1/2 | 670/1150 | 111/241 | 0.74 (0.57-0.96) | 0.022 | 690/1233 | 91/158 | 0.94 (0.70-1.26) | 0.660 | ||
ER expression | ||||||||||
Negative | 647/1150 | 102/241 | 0.71 (0.55-0.92) | 0.011 | 0.146 | 671/1233 | 78/158 | 0.85 (0.62-1.15) | 0.289 | 0.365 |
Positive | 50/1150 | 13/241 | 1.01 (0.51-1.98) | 0.982 | 54/1233 | 9/158 | 1.35 (0.65-2.81) | 0.428 | ||
PR expression | ||||||||||
Negative | 677/1150 | 110/241 | 0.73 (0.56-0.94) | 0.014 | 0.407 | 703/1233 | 84/158 | 0.87 (0.65-1.18) | 0.370 | 0.836 |
Positive | 20/1150 | 5/241 | 0.94 (0.32-2.80) | 0.911 | 22/1233 | 3/158 | 1.13 (0.33-3.84) | 0.851 |