Table 1 Logistic regression analysis of associations between genotypes of the LAMB3-miR-218 pathway and cervical cancer risk
From: A pri-miR-218variant and risk of cervical carcinoma in Chinese women
Variants Genotypes | Cases | Controls | P* | Crude OR | P | Adjusted OR | P** |
|---|---|---|---|---|---|---|---|
(N=1565) | (N=1391) | (95% CI) | (95%CI) | ||||
pri-miR-218 rs11134527 | |||||||
AA | 588 (37.6) | 512 (36.8) | 0.085 | 1.00 | 1.00 | ||
AG | 752 (48.1) | 638 (45.9) | 1.03 (0.88-1.20) | 0.748 | 1.03 (0.87-1.22) | 0.705 | |
GG | 225 (14.4) | 241 (17.3) | 0.81 (0.65-1.01) | 0.061 | 0.79 (0.63-0.99) | 0.039 | |
AG/GG | 977 (62.4) | 879 (63.2) | 0.668a | 0.97 (0.83-1.12) | 0.668 | 0.96 (0.82-1.13) | 0.648 |
Additive model | 0.93 (0.84-1.03) | 0.148 | 0.92 (0.82-1.02) | 0.111 | |||
Recessive model | 0.028 b | 0.80 (0.66-0.98) | 0.028 | 0.77 (0.63-0.95) | 0.015 | ||
LAMB3 rs2566 | |||||||
CC | 667 (42.6) | 570 (41.0) | 0.431 | 1.00 | 1.00 | ||
CT | 709 (45.3) | 663 (47.7) | 0.91 (0.78-1.07) | 0.252 | 0.89 (0.76-1.05) | 0.165 | |
TT | 189 (12.1) | 158 (11.4) | 1.02 (0.81-1.30) | 0.857 | 0.94 (0.73-1.21) | 0.642 | |
CT/TT | 898 (57.4) | 821 (59.0) | 0.366a | 0.94 (0.81-1.08) | 0.367 | 0.90 (0.77-1.05) | 0.186 |
Additive model | 0.98 (0.88-1.09) | 0.707 | 0.94 (0.84-1.06) | 0.325 | |||
Recessive model | 0.545b | 1.07 (0.86-1.34) | 0.546 | 1.00 (0.79-1.27) | 1.000 |