Figure 4

Unsupervised analysis of intragenic T-UCR cell line expression profiles. Subgroups of T-UCRs are expressed in three main clusters: Cluster 1, T-UCRs that are expressed anti-sense to the host gene expression; Cluster 2, T-UCRs that are expressed sense to host gene expression; Cluster 3, T-UCRs that are expressed both sense and anti-sense to host gene expression and show a significant over-representation of DNA binding proteins within their host genes relative to the other two clusters. Intragenic T-UCRs that are altered by ATRA are indicated with their host gene on the right side of the heatmap.