A combined blood based gene expression and plasma protein abundance signature for diagnosis of epithelial ovarian cancer - a study of the OVCAD consortium

Table 6 Characteristics of both combined models for diagnosis of EOC

Model	L1 lasso penalty	L2 ridge penalty
Blood expression values	5 genes	13 genes
Plasma protein values	5 proteins	6 proteins
AUC^a (FIGO I-IV)	0.998	0.998
AUC (FIGO I-II)	0.976	0.979
Specificity (set)	99.6%	99.6%
Sensitivity	97.8%	95.6%
Classification error (bootstrap .632+)	3.1%	2.8%

ISSN: 1471-2407