Table 3 Prognostic value of chemotherapy-associated lymphopenia <0.91 × 10 ⁹ /L for OS of colorectal cancer

Pretreatment albumin

≥35 g/L

1.00(ref.)

<35 g/L

1.140

0.648-2.007

0.649

Pretreatment CEA ^a

<10 ng ml^-1

1.00(ref.)

≥10 ng ml^-1

1. 900

1.056-3.416

0.032

Differentiation

Well

1.00(ref.)

Moderately

0. 865

0. 323–2.314

0.772

Low

1.097

0.311-3.871

0.885

Sex

Male

1.00(ref.)

Female

0.856

0.493-1.489

0.583

Age

≤49 years

1.00(ref.)

50-60 yeas

1.514

0.625-3.666

0.359

>60 years

1.587

0.698-3.607

0.271

Location

Rectum

1.00(ref.)

Left colon cancer

1.067

0.564-2.019

0.843

Right colon cancer

0.647

0.296-1.414

0.275

Stage

II

1.00(ref.)

III

3.641

1.980-6.697

<0.0001

Duration of lymphopenia <1.0 × 10 ⁹ L

≤28 days

1.00(ref.)

> 28 days

0.770

0.341-1.740

0.530

Chemotherapy-associated lymphocyte counts

Lymphocyte counts ≥ 0.66 × 10⁹/L

1.00(ref.)

Lymphopenia <0.66 × 10⁹/L

2.083

1.103-3.936

0.024