Figure 5
Aldehyde dehydrogenase I (ALDH-1) expression levels. Influence of CPA treatment on expression levels of ALDH-1 was determined in tumor tissue by qRT-PCR analysis after two treatments (HUH-PAS and HUH-REISO) and additional four treatments in the case of HUH-REISO (n=5). CPA therapy induced ALDH-1 expression in HUH-PAS (p=0.009) and in HUH-REISO (p=0.01) xenografts significantly. However, the ALDH-1 level was similar for passaged (HUH-PAS) and resistant (HUH-REISO) xenografts, independent of therapy. Statistic evaluation was performed using the Wilcoxon-Mann–Whitney test. P< 0.05 was considered as significant and indicated by *, p< 0.01 was indicated by **.