Effects of dabrafenib in melanoma cell lines. A . BRAF mutational status in our series of melanoma cell lines. B . Antiproliferative activity of increasing concentrations of dabrafenib in each cell line, as compared with the untreated (0) control. C . Inhibitory effects of dabrafenib on ERK1-2 phosphorylation, under the same experimental conditions (drug concentrations and time of treatment) as above.