Genetic variants in PARP1 (rs3219090) and IRF4(rs12203592) genes associated with melanoma susceptibility in a Spanish population

Table 2 Allelic frequencies in Spanish cases and controls

Gene	SNP	Minor allele	p-HWE	MAF Controls	MAF Cases	p-value	trend*
PARPI	rs3219090	A	0.27	0.329	0.275	0.023	0.028
CASP8	rs13016963	A	0.98	0.414	0.399	0.542	0.561
MX2	rs45430	G	0.93	0.380	0.392	0.624	0.603
CYP2R1	rs10741657	A	0.16	0.378	0.381	0.891	0.867
CCND1	rs1485993	T	0.48	0.448	0.438	0.697	0.652
NADSYN1	rs7944926	A	0.27	0.355	0.333	0.363	0.392
NADSYN1	rs12785878	G	0.75	0.369	0.330	0.102	0.109
ATM	rs1801516	A	0.04	0.145	0.121	0.185	0.208
IRF4	rs12203592	T	0.01	0.152	0.148	0.8	0.720

p-HWE: p-value obtained for deviation from Hardy-Weinberg Equilibrium. MAF: Minor Allele Frequency. Bold indicates statistically significant results.
*Trend p-values are obtained by performing a Cochran-Armitage test for trend.

ISSN: 1471-2407