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Table 5 Univariate analysis of clinical characteristics on progression free and overall survival in patients with metastatic non-small cell lung cancer

From: Advance lung cancer inflammation index (ALI) at diagnosis is a prognostic marker in patients with metastatic non-small cell lung cancer (NSCLC): a retrospective review

Variable

PFS: HR, (95% CI)

P = value

OS: HR, (95% CI)

P = value (a)

Age < 60

1.31 (0.96-1.79)

0.08

1.42 (1.03-1.95)

0.03

Gender (Female/Male)

1.14 (0.82-1.58)

0.41

0.97 (0.7-1.35)

0.88

Race (AA/White)

0.89 (0.65-1.20)

0.44

1.08 (0.8-1.47)

0.59

Histology (Adeno/Other)

1.03 (0.76-1.4)

0.82

1.01 (0.74-1.38)

0.90

PS (0-1/ 2–4)

0.62 (0.43-0.89)

0.009

0.64 (0.44-0.93)

0.01

Mets (1-2/ >2)

0.47 ( 0.34-0.64)

<0.0001

0.54 (0.39-0.73)

0.0001

No chemotherapy

2.25 (1.62-3.13)

<0.0001

2.36 (1.7-3.2)

<0.0001

ALC <1

1.61 (1.02-2.53)

0.03

1.82 (1.16-2.87)

0.009

NLR < 5

0.58 (0.42-0.8)

0.001

0.57 (0.41-0.79)

0.0008

ALI < 18

2.26 (1.65-3.09)

<0.0001

1.97 (1.45-2.68)

<0.0001

  1. a) Cox-proportional hazard regression model.
  2. Abbreviations: AA African Americans, Adeno Adenoacrinoma, ALC Absolute lymphocyte count, ALI Advanced lung cancer inflammation index, PS performance status, Mets metastatic sites, NLR Neutrophil/lymphocyte ratio. Significant results shown in bold.