Figure 2From: A first in human, safety, pharmacokinetics, and clinical activity phase I study of once weekly administration of the Hsp90 inhibitor ganetespib (STA-9090) in patients with solid malignancies Pharmacokinetic linearity plots. (A) AUC vs. Dose and (B) Cmax vs. Dose. Diamonds represent Day 1, triangles represent Day 15. Solid line represents linear regression of Day 1 and Day 15 data combined. Dotted line is Day 1 only. Dashed and dotted line is Day 15 only. For Days 1 and 15 combined, coefficients of determination for AUC and Cmax were 0.7547 and 0.7637, respectively.Back to article page