Insulin-like growth factor-1 genotypes and haplotypes influence the survival of prostate cancer patients with bone metastasis at initial diagnosis

Table 3 Univariate and multivariate analysis of clinicopathological and genetic factors predicting cancer-specific survival

Univariate analysis
	Category	HR¹	95% CI²	P
Clinical and pathological factors
Age (yrs)	≥ 72 vs. < 72	1.183	0.790 - 1.772	0.415
Gleason score	≥ 9 vs. < 9	1.759	1.151 – 2.687	0.009
PSA (ng/mL)	≥ 260 vs. < 260	1.510	0.992 – 2.299	0.054
HGB (g/dL)	< 11.5 vs. ≥ 11.5	2.251	1.261 – 4.019	0.006
ALP (IU/L)	≥ 350 vs. < 350	2.836	1.756 – 4.578	0.00002
LDH (IU/L)	≥ 500 vs. < 500	2.638	1.442 – 4.829	0.002
Genetic factors
LD block 1 (CA repeat)	19 rpts (+) vs. (-)	1.671	1.109 – 2.518	0.014
LD block 2 (rs12423791)	GC + CC vs. GG	1.658	1.102 – 2.495	0.015
LD block 3 (haplotype)	C-T (+) vs. C-T (-)	2.054	1.373 – 3.075	0.0005
Number of risk factors	0 vs. 1–2 vs. 3	1.578	1.208 – 2.060	0.0008
Number of risk factors	0–2 vs. 3	2.202	1.414 – 3.430	0.0005
*Multivariate analysis*
Full model
Age (yrs)	≥ 72 vs. < 72	0.919	0.554 – 1.526	0.745
Gleason score	≥ 9 vs. < 9	1.766	1.052 – 2.966	0.031
PSA (ng/mL)	≥ 265 vs. < 265	0.932	0.496 – 1.749	0.826
HGB (g/dL)	< 11.5 vs. ≥ 11.5	2.012	0.968 – 4.180	0.061
ALP (IU/L)	≥ 350 vs. < 350	2.598	1.483 – 4.551	0.0008
LDH (IU/L)	≥ 500 vs. < 500	1.836	0.977 – 3.448	0.059
LD Block 3 (haplotype)	C-T (+) vs. C-T (-)	2.619	1.559 – 4.399	0.0003
Reduced model
Gleason score	≥ 9 vs. < 9	1.709	1.054 – 2.771	0.030
HGB (g/dL)	< 11.5 vs. ≥ 11.5	2.082	1.113 – 3.897	0.022
ALP (IU/L)	≥ 350 vs. < 350	2.819	1.695 – 4.689	0.00007
LD Block 3 (haplotype)	C-T (+) vs. C-T (-)	2.626	1.603 – 4.305	0.0001

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