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Table 3 Univariate and multivariate analysis of clinicopathological and genetic factors predicting cancer-specific survival

From: Insulin-like growth factor-1 genotypes and haplotypes influence the survival of prostate cancer patients with bone metastasis at initial diagnosis

Univariate analysis
  Category HR1 95% CI2 P
Clinical and pathological factors
Age (yrs) ≥ 72 vs. < 72 1.183 0.790 - 1.772 0.415
Gleason score ≥ 9 vs. < 9 1.759 1.151 – 2.687 0.009
PSA (ng/mL) ≥ 260 vs. < 260 1.510 0.992 – 2.299 0.054
HGB (g/dL) < 11.5 vs. ≥ 11.5 2.251 1.261 – 4.019 0.006
ALP (IU/L) ≥ 350 vs. < 350 2.836 1.756 – 4.578 0.00002
LDH (IU/L) ≥ 500 vs. < 500 2.638 1.442 – 4.829 0.002
Genetic factors     
LD block 1 (CA repeat) 19 rpts (+) vs. (-) 1.671 1.109 – 2.518 0.014
LD block 2 (rs12423791) GC + CC vs. GG 1.658 1.102 – 2.495 0.015
LD block 3 (haplotype) C-T (+) vs. C-T (-) 2.054 1.373 – 3.075 0.0005
Number of risk factors 0 vs. 1–2 vs. 3 1.578 1.208 – 2.060 0.0008
0–2 vs. 3 2.202 1.414 – 3.430 0.0005
Multivariate analysis     
Full model     
Age (yrs) ≥ 72 vs. < 72 0.919 0.554 – 1.526 0.745
Gleason score ≥ 9 vs. < 9 1.766 1.052 – 2.966 0.031
PSA (ng/mL) ≥ 265 vs. < 265 0.932 0.496 – 1.749 0.826
HGB (g/dL) < 11.5 vs. ≥ 11.5 2.012 0.968 – 4.180 0.061
ALP (IU/L) ≥ 350 vs. < 350 2.598 1.483 – 4.551 0.0008
LDH (IU/L) ≥ 500 vs. < 500 1.836 0.977 – 3.448 0.059
LD Block 3 (haplotype) C-T (+) vs. C-T (-) 2.619 1.559 – 4.399 0.0003
Reduced model     
Gleason score ≥ 9 vs. < 9 1.709 1.054 – 2.771 0.030
HGB (g/dL) < 11.5 vs. ≥ 11.5 2.082 1.113 – 3.897 0.022
ALP (IU/L) ≥ 350 vs. < 350 2.819 1.695 – 4.689 0.00007
LD Block 3 (haplotype) C-T (+) vs. C-T (-) 2.626 1.603 – 4.305 0.0001
  1. 1HR, hazard ratio; 295% CI, 95% confidence interval.