Table 3 Copy number variants (CNVs) that were detected in primary, metastatic and recurrent tumors
From: Exome profiling of primary, metastatic and recurrent ovarian carcinomas in a BRCA1-positive patient
Region | Type | CNV segements indicating deletion/amplification | |||||
|---|---|---|---|---|---|---|---|
OV | OMN | REC | |||||
Coordinates | Mean log ratio | Coordinates | Mean log ratio | Coordinates | Mean log ratio | ||
1p35-1p36 | Del | 861393-12980233 | −0.3979 | 861322-27589726 | −0.5557 | 861322-27589726 | −0.5263 |
13910301-22895846 | −0.391 | 28059114-29652173 | −0.5209 | 28059114-29650008 | −0.5321 | ||
Chr4 | Del | 264888-42088143 | −0.1326 | 264888-1389640 | −0.5261 | 264888-1389640 | −0.5903 |
42145445-88235112 | −0.1643 | 20255439-145040934 | −0.5052 | 18023221-141832508 | −0.5217 | ||
88258428-190874280 | −0.1689 | 148785997-189026086 | −0.5084 | 147227078-190873442 | −0.5302 | ||
6q16-6q25 | Del | 153313992-170176161 | −0.2665 | 96971022-170893669 | −0.5104 | 96969750-170893669 | −0.5462 |
8p21-8p23 | Del | 117024-28385681 | −0.287 | 190896-28385681 | −0.5488 | 190896-28385681 | −0.5817 |
8q21-8q24 | Amp | 90775210-122641580 | 0.5658 | 90926305-95709154 | 0.5043 | 91836945-97172920 | 0.5658 |
123963751-142226069 | 0.98 | 97605708-122641580 | 0.927 | 97243283-121357802 | 0.9853 | ||
142227189-145278133 | 0.5909 | 123963751-145725582 | 1.3829 | 121379410-145622144 | 1.4429 | ||
145515440-146279543 | 0.5688 | ||||||
11q12-11q14 | Amp | 64676463p-134251918 | 0.1758 | 63581159-94354158 | 0.7324 | 63766427-94354158 | 0.7829 |
12p12-12p13 | Amp | 250451-6637339 | 0.1653 | 247439-22089608 | 0.4673 | 247439-22089608 | 0.4963 |
6638679-9262631 | 0.188 | ||||||
9264755-13140266 | 0.3317 | ||||||
13208485-31107009 | 0.2592 | ||||||
12q21-12q24 | Del | 31116761-121883221 | −0.1361 | 65078567-113909303 | −0.5148 | 64668681-133781116 | −0.5465 |
121970711-131616361 | −0.3135 | 114282473-133781116 | −0.55 | ||||
132195775-133781116 | −0.3871 | ||||||
16q21-16q24 | Del | 3725325-90142318* | −0.2189 | 50102691-90030718 | −0.5425 | 50069328-69988476 | −0.563 |
70428885-90142318 | −0.5792 | ||||||
17p + 17q11-17q21 | Del | 171206-7755654 | −0.3947 | 63643-36881851 | −0.5335 | 63643-36709091 | −0.5552 |
7758393-18286499 | −0.3397 | 36894606-41234592 | −0.5191 | 36865426-41256973 | −0.546 | ||
18539775-42328956 | −0.3036 | ||||||
19p13.3 | Del | 374421-8429523 | −0.448 | 474621-8194249 | −0.5189 | 110679-8402712 | −0.5409 |
19p13.2 | Amp | 8555110-11531615 | 0.1418 | 8429206-18541740 | 0.4018 | 8429206-10625687 | 0.4414 |
11559037-16639066 | 0.1043 | 10677734-11031424 | 0.8088 | ||||
11031510-18548570 | 0.4299 | ||||||
19q13.2-19q13.4 | Del | 17317922-59082756 | −0.2849 | 41626252-59082756 | −0.5468 | 41306478-59082756 | −0.5686 |
22q | Del | 17073440-18909917 | −0.362 | 16448824-51133476 | −0.517 | 17071767-51065188 | −0.5632 |
19029320-42999166 | −0.3716 | ||||||
43023310-51065480 | −0.4172 | ||||||