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Figure 2 | BMC Cancer

Figure 2

From: TRAIL and proteasome inhibitors combination induces a robust apoptosis in human malignant pleural mesothelioma cells through Mcl-1 and Akt protein cleavages

Figure 2

TRAIL induces a limited apoptosis in MPM cells. (A) Cell viability assay using WST-1 reagent indicates that 10–20 ng/ml RAIL induces a significant cell death at 72 h after treatment in NCI-H28 and NCI-H2452 cells, but not in NCI-H2052 cells. Values are expressed as the means ± SD of two experiments. *p < .05 versus control. (B) Western blotting demonstrates that 10–20 ng/ml TRAIL induces protein cleavage for caspase 3 and PARP at 42 h after treatment in NCI-H28 and NCI-H2452 cells, but not in NCI-H2052 cells. Protein cleavage fragments in Western blots are indicated by arrows.

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BMC Cancer

ISSN: 1471-2407

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