Figure 4
From: Time-dependent endpoints as predictors of overall survival in multiple myeloma
Predicted median overall survival (OS) versus the observed OS in randomized controlled trials (RCTs) including thalidomide-, bortezomib-, or lenalidomide-based regimens for post-transplantation maintenance therapy in multiple myeloma. Horizontal lines represent estimated 95% CIs for the median OS based on the modeled median time-dependent endpoints from each study arm. Solid circles represent observed median OS contained in the corresponding 95% CI estimate, and blue lozenge represents observed median OS not contained in the corresponding 95% CI estimate. Vertical dashed line stands for the mean of median OS of the no maintenance arms. Abbreviations: Bort, bortezomib; Dex, dexamethasone; Len, lenalidomide; Thal, thalidomide.