Table 3 Functional categories of genes up-regulated in breast tumor slices incubated in 100 nM 1,25(OH) 2 D 3
| Â | Genes up-regulated in VD3 100nM treated samples |
|---|---|
Biological process | Â |
Response to external stimulus | TGFBR2, LXN, THBD,PTEN, PTGER3, HBEGF, CYP24A1, ACVRL1, CCL19, FOXF1, FYN, OSM, CD28, CD14, BMP6, BMP2, PLAT, CD1D, PKD2, SERPINA1, PROCR, ALDH1A2 |
Response to wounding | TGFBR2, THBD, PTGER3, HBEGF, ACVRL1, CCL19, FOXF1, OSM, CD28, CD14, BMP6, BMP2, PLAT, SERPINA1, PROCR |
Regulation of leukocyte mediated immunity | CD226, FOXF1, DPP4, CD28, CD1D, GIMAP1 |
Pathway-restricted SMAD protein phosphorylation | TGFBR2, ACVR1B, BMP6, BMP2 |
Urogenital system development | CRLF1, PTEN, CYP19A1, BMP6, BMP2, CA2, PKD2, ALDH1A2 |
Vitamin metabolic process | TKTL1, SLC22A4, CYP24A1, DHRS9, MTAP, PSAT1, ALDH1A2 |
Positive regulation of alpha-beta T cell activation | TGFBR2, CD28, CD1D, GIMAP1 |
KEGG pathway | Â |
TGF-beta signaling pathway | TGFBR2, ACVRL1, ACVR1B, IDA, BMP6, BMP2 |
Drugs | Â |
Calcitriol | EFTUD1, EHBP1, TRIM56, HBEGF, CYP24A1, CYP19A1, ACVRL1, ACVR1B, SEMAD6D, ARRDC4, CD14, BMP6, PRKD1, BMP2, CLMN, PLAT, IL1RL1, PRKCH, SLC1A1, CA2, FAM20C, SHE |