Figure 1

Sensitization of C6 cells to radiation under hypoxia using doranidazole. Dose–response curves of X-irradiated C6 cells. Tumor cells were X-irradiated under normoxia (red closed circles), under normoxia with doranidazole (red open circles), under hypoxia (blue closed squares) and under hypoxia with doranidazole (blue open squares). The surviving fraction at each dose was calculated and corrected according to the plating efficiency of the nonirradiated control. Data are expressed as the mean ± S.E. for three experiments.