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Table 3 Aluminum content in peripheral areas of the tumor according to the clinical characteristics of the women and the pathological features of the tumors

From: Aluminum concentrations in central and peripheral areas of malignant breast lesions do not differ from those in normal breast tissues

Characteristics Total Aluminum content in mg/Kg
   Mean (sd)   Negative* 0.05 - 2.0 ≥ 2  
Age    P** n (%) n (%) n (%) P trend***
<40 20 1.71(1.79) 0.02 4 (16) 9 (10) 7 (20) 0.52
>4 0 130 1.97(3.81)   21 (84) 81 (90) 28 (80)  
BMI           
<25 46 2.13(1.06) 0.87 5 (31.2) 28 (36.8) 13 (39.4) 0.59
≥25 79 2.34(1.93)   11 (68.8) 48 (63.2) 20 (60.6)  
Menopausal status           
Post 42 2.09(2.33) 0.02 6 (35.3) 22 (27.8) 14 (40) 0.49
Pre 89 2.47(1.15)   11 (64.7) 57 (72.2) 21 (60)  
Quadrant           
Upper external 92 1.96(3.57) 0.86 14 (56) 56 (62.2) 22 (62.9) 0.61
Other 58 2.33(1.97)   11 (44) 34 (37.8) 13 (37.1)  
Tumor size           
<2.0 cm 72 2.31(7.23) 0.81 12 (48) 40 (44.9) 20 (58.8) 0.34
≥2.0 cm 76 1.92(3.77)   13 (52) 49 (55.1) 14 (41.2)  
Stage           
I-II 90 1.76(3.23) 0.48 13 (52) 56 (63.6) 21 (60) 0.61
III – IV 58 2.67(2.19)   12 (48) 32 (36.4) 14 (40)  
Histologic grade           
I-II 26 1.28(1.17) 0.83 5 (21.7) 16 (19.3) 5 (15.2) 0.52
III 113 2.40(2.48)   18 (78.3) 67 (80.7) 28 (84.8)  
Estrogen receptor           
Negative 40 1.77(1.57) 0.19 5 (21.7) 22 (25.6) 13 (38.2) 0.14
Positive 103 2.32(2.76)   18 (78.3) 64 (74.4) 21 (61.8)  
Progesterone receptor           
Negative 56 1.94(2.56) 0.15 7 (30.4) 32 (37.6) 17 (50) 0.12
Positive 86 2.31(7.20)   16 (69.6) 53 (62.4) 17 (50)  
cerbb2 status           
Negative 94 1.91(3.54) 0.09 17 (73.9) 52 (62.7) 25 (73.5) 0.86
Positive 46 1.91(4.07)   6 (26.1) 31 (37.3) 9 (26.5)  
  1. Note: The aluminum concentration was categorized as negative, 0.05-2.0 mg/ kg and ≥ 2.0 mg/ kg according to the three-tiered percentile distribution of the raw data. *Aluminum detection threshold for the GF-AAS was set at 0.05 mg/kg; ** In this column, the p values refer to the comparison of the mean Aluminum concentrations in each strata, using independent samples t-tests with the log-transformed (to base e) data; ***In this column, the p-values refer to the Chi-squares for trends; i.e. if p ≤ 0.05, there is a significant trend in Aluminum concentration related to the specified characteristic (see statistics for more details).
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