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Table 2 Vaccine efficacy parameters and assumptions

From: Estimating the clinical benefits of vaccinating boys and girls against HPV-related diseases in Europe

Gender

Male

Female

HPV genotype

6

11

16

18

6

11

16

18

Against transient infection †,‡

- Cervical, vaginal & vulvar diseases

41.1

62.1

76.0

96.3

- Genital warts & HPV 6, 11

49.0

57.0

76.1

76.1

Against persistent infection

- Anal disease

78.7

96.0

98.8

98.4

- Cervical, vaginal & vulvar diseases

98.8

98.4

- Penile disease

78.7

96.0

Against individual diseases

- Genital warts

84.3

90.9

98.9

100.0

  1. Unit: percentage. Values were derived from [17].
  2. Efficacy against genital infection in males is assumed to prevent transmission of genital infection to females, and vice versa.
  3. Efficacy for 1 and 2 doses assumed to be 23% and 45% of efficacy of the full 3 doses, respectively.
  4. *Efficacy against anal, head and neck, penile cancers is conferred through protection against infection only.