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Table 1 Targeted protein analysis of A2780 and A2780cis cells.

From: EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer

Protein Peptide Fragment Change Fold Mean Peak Area CV
     Sensitive Resistant Sensitive Resistant
E- cadherin   b8 -1.18 5.82E+04 3.22E+04 0.01 0.13
  GPFPKNLVQJK b9 -1.55 1.57E+04 1.01E+06 0.07 0.08
   b10 -1.63 3.33E+04 2.05E+04 0.03 0.19
   y8 -4.48 2.10E+04 5.02E+03 0.09 0.10
  VFYSITGQADTPPVGVFIIER y9 -4.16 8.25E+04 1.99E+04 0.02 0.12
   y10 -4.01 8.45E+04 2.11E+04 0.07 0.11
   y6 1.15 4.78E+06 2.52E+06 0.01 0.01
  EYQDLLNVK y7 1.14 2.19E+06 2.50E+06 0.02 0.01
Vimentin   y8 1.11 1.27E+05 1.14E+05 0.02 0.05
   y6 1.01 4.58E+06 4.62E+06 0.02 0.03
  ILLAELEQLK y7 1.08 7.34E+06 7.94E+06 0.04 0.05
   y8 1.10 1.11E+07 1.22E+07 0.04 0.04
   y9 1.08 1.35E+06 1.47E+06 0.04 0.04
   b3 1.25 6.00E+04 7.50E+04 0.14 0.03
Snail SFLVR b4 1.21 7.38E+04 8.89E+04 0.03 0.07
   y3 1.29 2.14E+04 2.76E+04 0.16 0.04
   b3 1.10 1.92E+04 2.10E+04 0.18 0.14
Slug HFNASK b5 1.27 2.40E+05 3.06E+05 0.06 0.16
   b10 1.05 9.96E+04 1.04E+05 0.13 0.07
  VSPPPPSDTSSK b11 1.19 4.47E+04 5.34E+04 0.07 0.05
   y9 1.24 4.00E+04 4.96E+04 0.07 0.06
  1. Summary of SRM-MS quantification results for E-Cadherin, Vimentin, Snail, and Slug. Mean peak area and coefficient of variation (CV) for each peptide fragment ion were derived from peak areas measured in three replicate assays of each of the sensitive and resistant cell line samples. Transitions with CV > 0.20 in either sample are not shown