Figure 2

Upregulation of genes associated with EMT in resistant cells. Genes known to 'regulate EMT were shown to be upregulated in the A2780cis cells compared to the A2780 cells. Data from the gene expression microarrays (a) and technical validation of snail and slug expression levels using qRT-PCR TaqMan assay (b) demonstrate that upregulation. Approximate fold change calculated as ΔΔCt for snail is 3.7 ± 0.3 (p-value = 0.0008) and for slug is 6.9 ± 0.4 (p-value = 0.001).