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Table 4 Mutation by age group and gender

From: Survival of gastrointestinal stromal tumor patients in the imatinib era: life raft group observational registry

Gene Exon/subunit < 18 18-35 > 35 Total
   F M F M F M  
KIT 11   1 8 6 71 100 186
  9    3 3 18 20 44
  13      2 5 7
Wild-type   10 2 25   12 8 57
PDGFRα 18     1 7 10 18
  12      3 2 5
  17      1   1
  Unknown       1 1
SDH C 2       2
  B    1 1    2
  Unknown      1   1
Unknown   9 4 45 33 352 409 852
Grand Total   21 7 82 44 467 555 1176
  1. Mutational status was reported by nearly one third of the cohort (n = 325). Patients of unknown age at diagnosis were not included (n = 31). Pediatric-type mutations include the wild-type GIST and SDH mutations. Wild-type GIST is a characteristic of pediatric-type GISTs, and 12 of 15 patients aged < 18 at diagnosis reported wild-type GIST. However, wild-type GIST is a heterogeneous mix that includes both adults and pediatric patients. KIT and PDGFRα mutations are broken out by exon, where known, whereas mutations within the succinate dehydrogenase complex denote subunits