Gene | Exon/subunit | < 18 | 18-35 | > 35 | Total |
---|
 |  | F | M | F | M | F | M |  |
---|
KIT | 11 | Â | 1 | 8 | 6 | 71 | 100 | 186 |
 | 9 |  |  | 3 | 3 | 18 | 20 | 44 |
 | 13 |  |  |  |  | 2 | 5 | 7 |
Wild-type | Â | 10 | 2 | 25 | Â | 12 | 8 | 57 |
PDGFRα | 18 |  |  |  | 1 | 7 | 10 | 18 |
 | 12 |  |  |  |  | 3 | 2 | 5 |
 | 17 |  |  |  |  | 1 |  | 1 |
 | Unknown |  |  |  |  |  | 1 | 1 |
SDH | C | 2 | Â | Â | Â | Â | Â | 2 |
 | B |  |  | 1 | 1 |  |  | 2 |
 | Unknown |  |  |  |  | 1 |  | 1 |
Unknown | Â | 9 | 4 | 45 | 33 | 352 | 409 | 852 |
Grand Total | Â | 21 | 7 | 82 | 44 | 467 | 555 | 1176 |
- Mutational status was reported by nearly one third of the cohort (n = 325). Patients of unknown age at diagnosis were not included (n = 31). Pediatric-type mutations include the wild-type GIST and SDH mutations. Wild-type GIST is a characteristic of pediatric-type GISTs, and 12 of 15 patients aged < 18 at diagnosis reported wild-type GIST. However, wild-type GIST is a heterogeneous mix that includes both adults and pediatric patients. KIT and PDGFRα mutations are broken out by exon, where known, whereas mutations within the succinate dehydrogenase complex denote subunits