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Table 4 Mutation by age group and gender

From: Survival of gastrointestinal stromal tumor patients in the imatinib era: life raft group observational registry

Gene

Exon/subunit

< 18

18-35

> 35

Total

  

F

M

F

M

F

M

 

KIT

11

 

1

8

6

71

100

186

 

9

  

3

3

18

20

44

 

13

    

2

5

7

Wild-type

 

10

2

25

 

12

8

57

PDGFRα

18

   

1

7

10

18

 

12

    

3

2

5

 

17

    

1

 

1

 

Unknown

     

1

1

SDH

C

2

     

2

 

B

  

1

1

  

2

 

Unknown

    

1

 

1

Unknown

 

9

4

45

33

352

409

852

Grand Total

 

21

7

82

44

467

555

1176

  1. Mutational status was reported by nearly one third of the cohort (n = 325). Patients of unknown age at diagnosis were not included (n = 31). Pediatric-type mutations include the wild-type GIST and SDH mutations. Wild-type GIST is a characteristic of pediatric-type GISTs, and 12 of 15 patients aged < 18 at diagnosis reported wild-type GIST. However, wild-type GIST is a heterogeneous mix that includes both adults and pediatric patients. KIT and PDGFRα mutations are broken out by exon, where known, whereas mutations within the succinate dehydrogenase complex denote subunits
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BMC Cancer

ISSN: 1471-2407

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